High-Throughput System for Protease Activity Profiling

描述（由申请人提供）：需要新技术来分析蛋白质组。我们建议开发一种分析蛋白酶活性的新技术。蛋白酶参与基本细胞过程的调节，蛋白水解活性的失调与许多疾病有关，如神经退行性疾病、心血管疾病、关节炎、阿尔茨海默病、癌症和传染病。

DESCRIPTION (provided by applicant): There is a need for new technologies to enable the analysis of the proteome. We propose to develop a novel technology for analyzing protease activity. Proteases are involved in the regulation of essential cellular processes and misregulation of proteolytic activity is involved in many diseases such as neurodegeneration, cardiovascular diseases, arthritis, Alzheimer's disease, cancer, and infectious diseases. PUBLIC HEALTH RELEVANCE: The protease activity profiling technology we are developing is useful for identifying new protease drug targets for drug development. It would help to elucidate the functional roles of specific proteases and may result in advances in the diagnosis and treatment of disease.