High-Throughput System for Protease Activity Profiling

描述(由申请人提供)：需要新技术来实现蛋白质组的分析。我们建议开发一种新的分析蛋白酶活性的技术。蛋白水解酶参与基本细胞过程的调节，蛋白分解活性的失调涉及许多疾病，如神经退行性变、心血管疾病、关节炎、阿尔茨海默病、癌症和传染病。 与公众健康相关：我们正在开发的蛋白酶活性图谱技术有助于识别新的用于药物开发的蛋白酶药物靶点。这将有助于阐明特定的蛋白酶的功能作用，并可能导致疾病的诊断和治疗方面的进展。

DESCRIPTION (provided by applicant): There is a need for new technologies to enable the analysis of the proteome. We propose to develop a novel technology for analyzing protease activity. Proteases are involved in the regulation of essential cellular processes and misregulation of proteolytic activity is involved in many diseases such as neurodegeneration, cardiovascular diseases, arthritis, Alzheimer's disease, cancer, and infectious diseases. PUBLIC HEALTH RELEVANCE: The protease activity profiling technology we are developing is useful for identifying new protease drug targets for drug development. It would help to elucidate the functional roles of specific proteases and may result in advances in the diagnosis and treatment of disease.