Microarray Technology for Proteomics Research

用于蛋白质组学研究的微阵列技术

• 批准号: 8129741
• 负责人: Igor A. Kozlov
• 金额: $ 84.73万
• 依托单位: PROGNOSYS BIOSCIENCES, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8129741
• 关键词: Affinity; Amino Acids; Autoimmune Diseases; Automation; Binding; Biological Assay; Cellulose; Code; Computer software; Coupled; DNA; Data; Data Analyses; Detection; Development; Diagnosis; Disease; Drug Delivery Systems; Epitope Mapping; Epitopes; Funding; Gene Expression; Generations; Genetic Transcription; Genetic Variation; Genome; Hypersensitivity; IgE; In Vitro; Individual; Influenza; Length; Link; Malignant Neoplasms; Medical; Methods; Microarray Analysis; Nucleic Acids; Oligonucleotides; Organism; Patients; Peptide Synthesis; Peptides; Performance; Phase; Plasma; Preparation; Procedures; Process; Production; Protein Analysis; Protein Array; Protein Binding; Proteins; Proteome; Proteomics; Protocols documentation; RNA; Reporting; Research; Robotics; Sampling; Screening procedure; Serum; Solid; Spottings; Surface; System; Techniques; Technology; Time; Transcription Process; Translation Process; Translations; Work; base; cost; density; design; drug development; method development; new technology; public health relevance; research study; software development

DESCRIPTION (provided by applicant): There is a need for new technologies to enable the analysis of the protein coding content of a genome. We propose to develop a novel technology for fabrication and analysis of highly multiplexed peptide microarrays at low cost. We will develop methods for array fabrication and utilization for large scale protein binding studies. PUBLIC HEALTH RELEVANCE: The protein array technology we are developing will help to enable large-scale studies of proteins. This is useful for identifying new drug targets and for drug development. It is also useful for analysis of protein abnormalities in autoimmune disease or cancer, and therefore may result in medical advances in the diagnosis and treatment of disease.

描述（由申请人提供）：需要新技术来分析基因组的蛋白质编码内容。我们建议开发一种新的技术，以低成本的高度多重肽微阵列的制造和分析。我们将开发用于大规模蛋白质结合研究的阵列制造和利用方法。 公共卫生相关性：我们正在开发的蛋白质阵列技术将有助于对蛋白质进行大规模研究。这对于确定新的药物靶点和药物开发是有用的。它也可用于分析自身免疫性疾病或癌症中的蛋白质异常，因此可能导致疾病诊断和治疗的医学进步。