Advanced Pixel Array Detector for Time-Resolved SAXS and Fiber Diffraction

描述（由申请人提供）：我们建议获得ADSC HF-1 M双模像素阵列检测器系统，以支持阿贡国家实验室高级光子源BioCAT Beamline 18 ID的静态和时间分辨光纤衍射和大分子小角溶液散射（SAXS）实验计划。BioCAT设施是NIH支持的生物技术研究中心（BTRC，9 P41 GM 103622 -18），承担此类资源所需的核心，协作和服务研究。从BioCAT BTRC的驱动生物医学项目中选择了拟议仪器的主要用户的核心组，这些项目涉及各种生物医学重要项目，如心脏和横纹肌调节，大分子折叠和大分子复合物的结构。一个相对稳定的国家卫生研究院资助的研究人员组成的服务用户的BioCAT设施的建议作为拟议的仪器的小用户。然而，BioCAT设施的使用权是根据同行评审的射束时间提案向所有人开放的，因此预计该名单的规模将随着时间的推移而大幅增长，范围也将扩大。该探测器的一个重要用途是与BioCAT项目内的核心技术开发计划相配合，开发新的仪器和技术，使该设施的所有用户受益。这些包括毫秒时间分辨率肌肉衍射和 停止流动SAXS实验以及<100微秒时间分辨率连续流动SAXS实验。所提出的探测器提供的使能技术能够在500 Hz（双光子计数和积分模式）或1 kHz（光子计数）下提供1 k x 1 k，150 μ m像素，160 x 160 mm正方形帧，帧间仅为1微秒，与BioCAT时间分辨解决方案SAXS和肌肉衍射程序接近理想匹配。与现有探测器相比，信噪比的提高和更快的帧速率将使这些实验从仅仅是可能的转变为实用和有效的，从而造福于广大的科学界。

DESCRIPTION (provided by applicant): We propose to acquire a ADSC HF-1M Dual Mode Pixel Array Detector system to support the static and time-resolved fiber diffraction and macromolecular small-angle solution scattering (SAXS) experimental programs at the BioCAT Beamline 18ID at the Advanced Photon Source, Argonne National Laboratory. The BioCAT facility is a NIH supported Biotechnology Research Center (BTRC, 9 P41 GM103622-18) that undertakes the core, collaborative and service research required of such resources. A core group of major users of the proposed instrument has been selected from the Driving Biomedical Projects for the BioCAT BTRC that address a diverse array of biomedically important projects such as cardiac and striated muscle regulation, macromolecular folding and the structure of macromolecular complexes. A relatively stable group of NIH funded investigators comprising service users of the BioCAT facility are proposed as minor users of the proposed instrument. Access to BioCAT facilities, however, are open to everyone on the basis of peer-reviewed beamtime proposals so this list is expected to grow substantially in size and expand in scope with time. An important use of the detector will be in concert with core technology development programs within the BioCAT project that develop new instruments and techniques that can benefit all users of the facility. These include millisecond time resolution muscle diffraction and stopped flow SAXS experiments as well as <100 microsecond time resolution continuous flow SAXS experiments. The enabling technology provided by the proposed detector is the ability to provide 1k x 1k, 150 ¿m pixel, 160 x 160 mm square frames at either 500 Hz (dual photon counting and integrating mode) or 1 kHz (photon counting) with only 1 micro-second between frames, providing a close to ideal match to the BioCAT time resolved solution SAXS and muscle diffraction programs. The improved signal to noise over existing detectors and faster frame rates will transform these experiments from being just possible to being practical and efficient to the benefit of the broad scientific community.