Support of Yerkes National Primate Research Center

 描述(由申请人提供)：这一竞争性修订申请寻求对耶克斯基础拨款(P51 OD 11132)的额外支持，该拨款将允许通过纳入新英格兰灵长类研究中心(NEPRC)的无特定病原体(SPF)动物来扩大猕猴无特定病原体(SPF)群体。在本报告所述期间(2011年5月1日至今)，YNPRC取得了实质性进展，这反映在540多份出版物中，建造了新的动物设施，并逐步扩大了其研究资金基础，即使在国家卫生研究院资金竞争极其激烈的时代也是如此。我们研究基础的持续增长，加上研究人员对具有良好遗传特征的非人类灵长类动物的更专门要求，已经使我们现有的恒河猴SPF繁殖群体的能力变得紧张，并导致需要从外部来源获得大量动物。在欧力普领导层的支持下，耶克斯已经与NEPRC合作，促进了大约135头SPF繁殖动物从NEPRC SPF群体中的转移。将这些动物纳入Yerkes SPF育种计划将增强该中心作为核心研究人员和国内外科学家的资源的能力，所有这些都是为了促进人类健康的最终目标。这些补充活动与我们的核心目标非常一致，即支持专注于与人类健康相关的科学问题的研究计划，并提供适当科学和兽医专业的资源基础设施和专业知识来支持此类研究。

 DESCRIPTION (provided by applicant): This competing revision application seeks additional support for the Yerkes Base Grant (P51 OD 11132) that will allow expansion of the rhesus macaque specific pathogen free (SPF) colony by the inclusion of SPF animals from the New England Primate Research Center (NEPRC). The YNPRC has recorded substantial progress in the present reporting period (5/1/2011 - present), as reflected in over 540 publications, construction of new animal facilities, and progressive expansion of its research funding base, even in the era of an extremely competitive NIH funding environment. The continued growth of our research base, coupled with the more specialized demands of investigators for genetically well-characterized nonhuman primates, have strained the capacity of our existing rhesus macaque SPF breeding colony, and resulted in the need to obtain significant numbers of animals from outside sources. With the support of ORIP leadership, Yerkes has partnered with the NEPRC to facilitate the transfer of approximately 135 SPF breeding animals from the NEPRC SPF colony. The incorporation of the animals into the Yerkes SPF breeding program will enhance the Center's ability to serve as a resource to core investigators and to scientists nationally and internationally, all for the ultimate goal of advancing human health. These supplemental activities are well-aligned with our central goals of supporting research programs focused on scientific problems relevant to human health, and providing the resource infrastructure and expertise in appropriate scientific and veterinary specialties to support such research.