DEVELOPING A GENERAL POPULATION JOB EXPOSURE MATRIX FOR STUDIES OF WORK-RELATED MSD

摘要 工作场所身体暴露的评估是工作相关研究的一个关键方面 肌肉骨骼疾病(MSD)和其他可能受工作场所影响的疾病 身体暴露，包括血管疾病、妊娠结局、癌症和工作 残疾。职务暴露矩阵(JEM)将编码的职务转换为暴露估计值。而当 JEM经常用于职业性癌症的研究，JEM未被充分利用来估计 肌肉骨骼和其他慢性病研究中的工作场所物理暴露。在……里面 对于这样的研究，除了效率之外，JEM还有两个额外的优势：它们可以 减少案例和非案例之间的信息偏差，并允许估计 如果没有其他可用的此类数据，则应提供暴露数据。使用最近一次大型 在法国劳动适龄成年人队列中，我们的研究将建立一个普通人口JEM，以使 关于工作场所身体暴露与慢性疾病之间关系的大规模研究 疾病；比较来自法国的数据和来自美国JEM的暴露； 将两个JEM的暴露估计值与从一个大型美国人观察到的暴露值进行比较 队列研究；使用已知关联在法国人口数据集中验证JEM 物理暴露和MSD之间的关系；并通过测试其 能够复制已知的暴露反应与事件上肢MSD的关联 一项大型的美国队列研究。 本研究的总体目标是扩展和验证JEM的使用，以便提供 能够将工作暴露添加到包括健康在内的许多美国普通人口数据集 结果和职称，但没有其他工作接触数据。我们还将创建一个法国JEM 将极大地扩展研究人员研究工作场所物理影响的能力 一项激动人心的关于工作年龄的新的大型纵向研究揭示了许多健康后果 法国的成年人。这一能力将促进对多种相关健康后果的更多研究 到工作场所的身体暴露。我们提议的研究直接回应了战略上的 当前NIOSH中指定的NORA暴露评估跨部门目标 校外研究的优先目标：“制定或改进暴露评估战略，以 了解和预防与工作有关的疾病和伤害“，以及”制定或改进具体的 评估工人暴露于关键职业制剂和压力源的方法和工具。 这项研究也与Nora肌肉骨骼疾病计划的目标有关。

ABSTRACT Assessment of workplace physical exposures is a critical aspect of research into work-related musculoskeletal disorders (MSD) and other conditions that may be affected by workplace physical exposures, including vascular disease, pregnancy outcomes, cancers, and work disability. Job exposure matrices (JEMs) convert coded job titles into exposure estimates. While JEMs are frequently used in studies of occupational cancers, JEMs are underutilized to estimate workplace physical exposures in studies of musculoskeletal and other chronic diseases. In addition to their efficiency, JEMs have two additional advantages for such studies: they can decrease information bias between cases and non-cases, and they allow the estimation of exposure data when no such data are otherwise available. Using data from a recent large cohort of working age adults in France, our study will build a general population JEM to enable large-scale studies of associations between workplace physical exposures and chronic diseases; compare exposures derived from the French data to those from an American JEM; compare exposure estimates from both JEMs to observed exposures from a large American cohort study; validate the JEM in a French population dataset using known associations between physical exposures and MSD; and further validate JEM exposures by testing their ability to replicate known exposure response associations with incident upper extremity MSD in a large American cohort study. The overall goal of this study is to expand and validate the use of JEMs in order to provide the ability to add work exposures to the many US general population data sets that include health outcomes and job titles, but no other work exposure data. We will also create a French JEM that will greatly expand the ability of researchers to study the effects of workplace physical exposures on many health outcomes in an exciting new large longitudinal study of working age adults in France. This capability will spur additional studies of multiple health outcomes related to workplace physical exposures. Our proposed study is directly responsive to both strategic goals of the NORA Exposure Assessment Cross- Sector designated in the current NIOSH Priority Goals for Extramural Research: “Develop or improve exposure assessment strategies to understand and prevent work-related illnesses and injuries,” and “Develop or improve specific methods and tools to assess worker exposures to critical occupational agents and stressors.” The study is also relevant to goals of the NORA Musculoskeletal Disorders Program.