CTSA INFRASTRUCTURE FOR CLINICAL TRIALS

本分项目是CTSA供资的估计百分比，即 被用于广泛的研究领域(艾滋病研究、儿科研究或 临床试验)。列出的总成本仅是对CTSA金额的估计 用于这一研究领域的基础设施，而不是由 授予子项目或子项目工作人员的NCRR补助金。 这项来自圣路易斯华盛顿大学(吴)的CTSA申请建立在出色的生物医学研究、研究培训和患者护理方面的悠久机构历史之上。吴是构成CTSA基础的4项临床研究和培训赠款的获得者(GCRC目前处于其第46个资助年头，以及K12、K30和T32赠款。)另一个关键因素是吴在基因组科学、生物成像和临床研究方面的多学科合作研究方面的新的BioMed 21战略倡议。所有这些要素将与吴的其他现有资源结合起来，形成一个变革性的新的临床与翻译科学研究所(ICTS)。通过实施本申请中描述的15项关键计划功能，ICTS将在概念和操作上重塑和重振吴的临床和转化性研究以及临床研究培训。与其他学术、医疗保健、社区和科学机构的伙伴关系达到前所未有的水平，补充了我们在实验室和临床研究以及研究培训方面的核心专业知识，这对ICTS将引领的变革至关重要。我们的合作伙伴包括BJC Healthcare，一个整合的学术和社区医疗保健提供系统；圣路易斯大学公共卫生学院、研究生院和多西健康科学学院；密苏里大学圣路易斯护理学院；南伊利诺伊大学爱德华兹维尔护理学院；圣路易斯药学院；促进社区健康的关键组织以及圣路易斯地区的生物医学和制药公司。这些资源的结合创造了一个出色的环境，使基本的实验室发现可以转化为临床研究方案，并最终通过广泛的社区互动和商业合作伙伴关系在临床实践和患者护理方面取得进展。“为了确保ICTS的成功，吴做出了大量的空间和资金支持。我们的学术医院-犹太医院和圣路易斯儿童医院，我们的学术医院合作伙伴兰德-BDC医疗保健，我们的附属医疗系统，也对ICTS的临床研究活动做出了重大承诺。这些额外的资源，加上现有的临床和翻译科学的高质量计划，确保了吴将为NIH的这一倡议做出杰出的贡献。

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. This CTSA application from Washington University in St. Louis (WU) is built on a long institutional history of outstanding biomedical research, research training, and patient care. WU is the recipient of the 4 clinical research and training grants that form the basis of the CTSA (GCRC, currently in its 46th year of funding, and K12, K30, and T32 grants.) Another critical element is WU's new BioMed 21 strategic initiative in multidisciplinary, collaborative research in genome sciences, biological imaging, and clinical investigation. All these elements will be conjoined with other existing resources at WU to form a transformational new Institute of Clinical and Translational Sciences (ICTS). By implementing the 15 key Program Functions described in this application, the ICTS will conceptually and operationally reinvent and reinvigorate clinical and translational research and clinical research training at WU. An unprecedented level of partnership with other academic, healthcare, community and scientific institutions that complement our core expertise in laboratory and clinical research and research training is central to the transformation that will be led by the ICTS. Our partners include BJC HealthCare, an integrated academic and community health care delivery system; Saint Louis University School of Public Health, Graduate School and Doisy College of Health Sciences; University of Missouri St. Louis College of Nursing; Southern Illinois University Edwardsville School of Nursing; and St. Louis College of Pharmacy; key organizations promoting community health as well as biomedical and pharmaceutical companies in the St. Louis area. The coupling of these resources creates an outstanding environment to make basic laboratory discoveries that can then be translated into clinical research protocols and ultimately into advances in clinical practice and patient care through extensive community interactions and commercial partnerships." To ensure the success of the ICTS, WU has made substantial commitments of space and financial support. Barnes-Jewish and St. Louis Children's Hospitals, our academic hospital-partnersrand-BdC HealthCare, our affiliated health system, have also made substantial commitments to the clinical research activities of the ICTS. These additional resources coupled with the existing high quality programs in clinical and translational science ensure that WU will make outstanding contributions to this NIH initiative.