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Development of a Tick Transmission Model for Heartland Virus Pathogenesis

开发心脏地带病毒发病机制的蜱传播模型

基本信息

批准号：
9086217
负责人：
Saravanan Thangamani
金额：
$ 19.38万
依托单位：
UNIVERSITY OF TEXAS MED BR GALVESTON
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-06-15 至 2018-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9086217
关键词：
Address Amblyomma Animal Model Animals Bite Bunyaviridae Case Fatality Rates Cavia China Clinical Clinical Pathology Competence Crimean Hemorrhagic Fever Development Diagnostic tests Disease Disease Outbreaks Emerging Communicable Diseases Family Fatal Outcome Fever Funding Future Genus Phlebovirus Geographic Distribution Hamsters Hantavirus Pulmonary Syndrome Health Heartland virus Human Immune response Incidence Infection Investigation Knowledge Laboratory Animals Lassa Fever Lead Missouri Modeling Mouse Strains Mus Onset of illness Outcome Pathogenesis Predisposition Prevention Public Health RNA Viruses Reporting Research Rocky Mountain Spotted Fever Severity of illness Smallpox Symptoms Syndrome Therapeutic Agents Thrombocytopenia Tick-Borne Diseases Ticks Time Transgenic Mice United States Virus Virus Diseases Work Yellow Fever feeding innovation men novel diagnostics pathogen response therapeutic vaccine tool development transmission process vaccine candidate vector virus pathogenesis

项目摘要

DESCRIPTION (provided by applicant): A new tick-borne virus, Heartland virus (HLV), associated with severe febrile illness has recently been reported in the US. HLV is closely related to the severe fever with thrombocytopenia syndrome virus (SFTSV), a tick transmitted virus, with a case fatality rate as high as 30%, putting it on par with yellow fever, Lassa fever, hantavirus pulmonary syndrome, Crimean-Congo hemorrhagic fever, and untreated Rocky Mountain spotted fever. As HLV is a newly described virus in the US, its the incidence of infection, range of disease severity and pathogenesis are currently unknown. So far, 6 human cases have been reported with one fatal case. Lack of an animal model is a critical barrier to understand the pathogenesis and host immune response to HLV infection, and also impedes development of tools for prevention and control of HLV infection. The proposed study is innovative in that it is the first to develop an animal model for HLV infection by infected tick bites, and also in its rapid response to a newly identified human pathogen. This study will have an impact on US public health, and will further advance our current understanding of HLV infection and probably SFTSV infection as well.

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Tick-Borne Viruses and Biological Processes at the Tick-Host-Virus Interface.

DOI：
10.3389/fcimb.2017.00339
发表时间：
2017
期刊：
Frontiers in cellular and infection microbiology
影响因子：
5.7
作者：
Kazimírová M;Thangamani S;Bartíková P;Hermance M;Holíková V;Štibrániová I;Nuttall PA
通讯作者：
Nuttall PA

Powassan Virus: An Emerging Arbovirus of Public Health Concern in North America.