Project 6: Airborne Exposures to Semi-volatile Organic Pollutants (The AESOP Study)

项目总结 伊索研究(空气中暴露于半挥发性有机污染物)是一项以社区为基础的参与者- 一项在城市队列中评估大气中多氯联苯暴露和身体负担的保守主义研究 在一个被遗留多氯联苯污染的地区，疏浚350万立方米的儿童和他们的母亲 对多氯联苯沉淀物的研究正在进行中。空气中的多氯联苯暴露，加上血清和尿液中的多氯联苯和 对代谢物进行评估，并与疏浚开始前队列中的水平以及农村地区的水平进行比较 爱荷华州在一个没有遗留多氯联苯的地区。伊索研究正在确定印刷电路板博览会的决定因素- 儿童及其母亲的安全，包括室内和室外暴露水平、饮食摄入量和其他 暴露途径。这项研究还在确定我们如何最好地监测暴露和代谢物。这个 具体目标是：1：维护东芝加哥和哥伦布交界处的城乡居民群 并收集受试者的人口、居住、职业、活动、饮食和基线健康数据；2： 收集家庭和学校内外的空气样本，并测量同种物质的特定浓度 大气中的多氯联苯；3：每年从所有受试者采集血液，并测量多氯联苯和多氯联苯的同系物- 血清样本中的特定代谢物并将这些值报告给参与者；4：收集所有受试者的尿液 并测量同系物特异性的多氯联苯硫酸盐代谢物，并评估尿液作为生物标志物的有效性 暴露于较低氯化的同系物；和5：大气多氯联苯的模型暴露和身体负担 来自队列的同类者并比较建模数据和测量数据。这些目标是由强大的 通过我们的社区参与核心并通过样本分析获得的社区支持 在我们的分析核心中执行。伊索研究雇用了双语社区外勤工作人员，并 在这些种族和民族多元化的社区中登记并跟踪了264名受试者(59%西班牙裔，23% 黑色，其他18%)，并对空气中暴露和由此造成的身体负担提供了新的见解。曝光量 通过反复采集受试者家中内外和当地的空气样本进行评估 还通过每年采集血液和化验多氯联苯的同系物和代谢物。这个 伊索研究为爱荷华州超级基金研究的其他组成部分提供了人体样本和数据 提供增强相关性的计划。在这个更新周期中，我们将更详细地评估我们的 受试者使用既定的方法。这些饮食信息将与吸入数据一起使用，并 用于集成曝光建模的活动日志。伊索研究改变了主流观点，即大多数人 美国人暴露在多氯联苯中。我们已经证明，我们的研究对象对多氯联苯有很大的接触 同系物来自吸入和摄取，他们的血液显示吸入较低的- 氯化的同系物。这对儿童的环境健康具有重要影响。

PROJECT SUMMARY The AESOP Study (Airborne Exposures to Semi-volatile Organic Pollutants) is a community-based participa- tory research study that assesses exposures and body burdens of atmospheric PCBs among an urban cohort of children and their mothers in an area contaminated with legacy PCBs and where dredging of 3.5 million m3 of PCB-laden sediments is now underway. Airborne PCB exposures, plus serum and urine levels of PCBs and metabolites, are assessed and compared to levels in the cohort before the dredging began as well as to a rural Iowa cohort in an area without legacy PCBs. The AESOP Study is identifying the determinants of PCB expo- sures among children and their mothers including exposure levels indoors and out, dietary intake and other exposure pathways. The Study is also determining how we can best monitor exposures and metabolites. The Specific Aims are: 1: Maintain the urban and rural residential cohorts in East Chicago and Columbus Junction and gather demographic, residential, occupational, activity, dietary and baseline health data from subjects; 2: Collect air samples inside and outside at homes and schools and measure congener-specific concentrations of atmospheric PCBs; 3: Collect blood annually from all subjects and measure PCB congeners and congener- specific metabolites in serum samples and report these values to participants; 4: Collect urine from all subjects and measure congener-specific PCB sulfate metabolites and evaluate the efficacy of urine as a biomarker for exposure to lower-chlorinated congeners; and 5: Model exposures and body burdens for the atmospheric PCB congeners from the cohorts and compare modeled and measured data. These aims are facilitated by strong community support garnered through our Community Engagement Core and aided by sample analyses performed in our Analytical Core. The AESOP Study employs bilingual community-based field staff and has enrolled and followed 264 subjects in these racially and ethnically diverse communities (59% Hispanic, 23% Black, 18% other) and provided new insight into airborne exposures and resulting body burdens. Exposures have been assessed through repeated air sampling inside and outside of homes of subjects and at their local schools and also through annual blood collection and assay for PCB congener and metabolite profiles. The AESOP Study provides human samples and data to other components of the Iowa Superfund Research Program providing enhanced relevance. In this renewal cycle, we will evaluate in greater detail the diet of our subjects using established methodology. This dietary information will be used along with inhalation data and activity logs for integrated exposure modeling. The AESOP Study has changed prevailing views on how most Americans are exposed to PCBs. We have demonstrated that our subjects have substantial exposure to PCB congeners from inhalation in addition to ingestion and their blood shows enrichment with inhaled lower- chlorinated congeners. This has important implications for children's environmental health.