Project 6: Airborne Exposures to Semi-volatile Organic Pollutants (The AESOP Study)

项目摘要 AESOP研究（空气中半挥发性有机污染物暴露）是一项以社区为基础的研究， 一项评估城市人群中大气中多氯联苯暴露和身体负担的历史研究 在被遗留的多氯联苯污染的地区， 多氯联苯沉积物的研究正在进行中。空气中的多氯联苯接触，加上血清和尿液中的多氯联苯含量， 代谢物，进行评估，并与疏浚开始前的队列水平以及农村地区进行比较。 爱荷华州队列在一个地区没有遗留的多氯联苯。AESOP研究正在确定PCB博览会的决定因素， 儿童及其母亲的接触水平，包括室内和室外的接触水平、饮食摄入量和其他 暴露途径。该研究还确定了我们如何最好地监测暴露和代谢物。的 具体目标是：1：保持东芝加哥和哥伦布交界处的城市和农村居民群 收集受试者的人口统计学、居住、职业、活动、饮食和基线健康数据; 2： 收集家庭和学校内外的空气样本，并测量 大气中的多氯联苯; 3：每年收集所有受试者的血液，并测量多氯联苯同系物和同系物- 血清样本中的特定代谢物，并将这些值报告给参与者; 4：收集所有受试者的尿液 并测量同源特异性PCB硫酸盐代谢物，并评估尿液作为生物标志物的功效， 5：大气中多氯联苯的接触模式和人体负荷 同源物，并比较建模和测量数据。这些目标是由强大的 通过我们的社区参与核心和样本分析获得的社区支持 在我们的分析核心中执行。AESOP研究雇用了双语社区实地工作人员， 在这些种族和民族多样化的社区中招募并随访了264名受试者（59%为西班牙裔，23%为美国裔，24%为美国裔，25%为美国裔）。 黑色，18%其他），并提供了新的见解空气中的暴露和由此产生的身体负担。暴露 通过在受试者的家中和家中以及他们当地的反复空气采样进行评估 此外，还通过每年的血液采集和多氯联苯同系物和代谢物分析。的 AESOP研究为爱荷华州超级基金研究的其他组成部分提供人体样本和数据 提供增强相关性的方案。在这个更新周期中，我们将更详细地评估我们的饮食， 使用已建立的方法。该饮食信息将与吸入数据一起沿着使用， 活动日志用于集成暴露建模。AESOP研究改变了人们对大多数人 美国人接触到多氯联苯。我们已经证明，我们的受试者有大量接触多氯联苯 除摄入外，还吸入了同系物，其血液显示出吸入较低浓度的富集， 氯化同系物。这对儿童的环境健康具有重要影响。

PROJECT SUMMARY The AESOP Study (Airborne Exposures to Semi-volatile Organic Pollutants) is a community-based participa- tory research study that assesses exposures and body burdens of atmospheric PCBs among an urban cohort of children and their mothers in an area contaminated with legacy PCBs and where dredging of 3.5 million m3 of PCB-laden sediments is now underway. Airborne PCB exposures, plus serum and urine levels of PCBs and metabolites, are assessed and compared to levels in the cohort before the dredging began as well as to a rural Iowa cohort in an area without legacy PCBs. The AESOP Study is identifying the determinants of PCB expo- sures among children and their mothers including exposure levels indoors and out, dietary intake and other exposure pathways. The Study is also determining how we can best monitor exposures and metabolites. The Specific Aims are: 1: Maintain the urban and rural residential cohorts in East Chicago and Columbus Junction and gather demographic, residential, occupational, activity, dietary and baseline health data from subjects; 2: Collect air samples inside and outside at homes and schools and measure congener-specific concentrations of atmospheric PCBs; 3: Collect blood annually from all subjects and measure PCB congeners and congener- specific metabolites in serum samples and report these values to participants; 4: Collect urine from all subjects and measure congener-specific PCB sulfate metabolites and evaluate the efficacy of urine as a biomarker for exposure to lower-chlorinated congeners; and 5: Model exposures and body burdens for the atmospheric PCB congeners from the cohorts and compare modeled and measured data. These aims are facilitated by strong community support garnered through our Community Engagement Core and aided by sample analyses performed in our Analytical Core. The AESOP Study employs bilingual community-based field staff and has enrolled and followed 264 subjects in these racially and ethnically diverse communities (59% Hispanic, 23% Black, 18% other) and provided new insight into airborne exposures and resulting body burdens. Exposures have been assessed through repeated air sampling inside and outside of homes of subjects and at their local schools and also through annual blood collection and assay for PCB congener and metabolite profiles. The AESOP Study provides human samples and data to other components of the Iowa Superfund Research Program providing enhanced relevance. In this renewal cycle, we will evaluate in greater detail the diet of our subjects using established methodology. This dietary information will be used along with inhalation data and activity logs for integrated exposure modeling. The AESOP Study has changed prevailing views on how most Americans are exposed to PCBs. We have demonstrated that our subjects have substantial exposure to PCB congeners from inhalation in addition to ingestion and their blood shows enrichment with inhaled lower- chlorinated congeners. This has important implications for children's environmental health.