Integrative Health Sciences Core

综合健康科学核心

• 批准号: 8279703
• 负责人: Peter S Thorne
• 金额: $ 18.96万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8279703
• 关键词: Acute; Aerosols; Award; Biological; Bronchoscopy; Charge; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Services; Collaborations; Development; Disease; Ensure; Environment; Environmental Exposure; Environmental Health; Exposure to; Fees; Funding; Funding Agency; Gases; Goals; Health; Health Sciences; Human; Image; Industry; Institutes; Institutional Review Boards; Interdisciplinary Study; Investigation; Investments; Iowa; Lung; Measurement; Modality; Monitor; Physiological; Policies; Preparation; Process; Protocols documentation; Pulmonary function tests; Recruitment Activity; Reproducibility; Research; Research Design; Research Infrastructure; Research Personnel; Research Subjects; Resources; Safety; Sampling; Services; Solutions; Specimen; Training; Training and Infrastructure; Translating; Translational Research; United States National Institutes of Health; Universities; cost; cost shifting; discount; experience; exposed human population; health science research; human subject; injured airway; interdisciplinary collaboration; interest; multidisciplinary; patient oriented; research facility; research study; response; response to injury; translational study

9.1.2 Rationale for Goals and Aims The IHSF is a central component of the EHSRC, promoting human-centered research. An emphasis on human studies has been a long-standing strength of the EHSRC; this facility provides the infrastructure to conduct such studies with safety (to both research subjects and investigators), reproducibility, and rigorous scientific approaches. The IHSF supports radiological imaging, bronchoscopies, and other services needed to translate basic investigations into clinical studies. A significant change in the IHSF since our previous application has been driven by the awarding of a Clinical and Translational Science Award (CTSA) to the U.I. ICTS. This development has led to a significant (over $10 million) investment by the University into research infrastructure and facilities from which our EHSRC investigators can benefit. Although the ICST provides outstanding facilities available for human research, its strengths are centered on subject interactions; the IHSF provides support in specific research modalities, including human exposures, enhanced pulmonary function testing, bronchoscopy, and imaging for EHS-related research. We have enhanced the Center services to ensure that EHSRC researchers are able to maximize the potential for translational environmental health science research. Being able to access both ICTS resources as well as EHSRC facilities is a great opportunity for center investigators. We will support investigators using these state-of-the-art facilities by enhanced study design, IRB support, measurements, biological sampling. and specimen analyses. Furthermore, we will subsidize the costs of using the ICTS facilities. The University of Iowa ICST has initiated a policy of recharges for all studies. This is gradated by funding source, so that industry-initiated, industry-sponsored trials are charged the actual cost of providing services (including protocol review, document preparation, clinical services, etc), and NIH-funded studies are charged discounted fees, generally by 50%. Because we recognize that this cost-shifting will provide a barrier for new and non-funded investigators; to support our investigators, we propose to cover a substantial portion of this

9.1.2目标和宗旨的理由 IHSF是EHSRC的核心组成部分，促进以人为本的研究。对人体研究的重视一直是EHSRC的长期优势;该设施提供了进行此类研究的基础设施，具有安全性（对研究对象和研究人员），可重复性和严格的科学方法。IHSF支持放射成像、支气管镜检查和将基础研究转化为临床研究所需的其他服务。 自我们之前的申请以来，IHSF的一个重大变化是由U.I.获得临床和转化科学奖（CTSA）推动的。信通技术。这一发展导致了大学对研究基础设施和设施的重大投资（超过1000万美元），我们的EHSRC调查人员可以从中受益。尽管ICST为人类研究提供了出色的设施，但其优势集中在受试者互动上; IHSF为特定的研究模式提供支持，包括人体暴露，增强肺功能测试，支气管镜检查和EHS相关研究的成像。我们加强了中心的服务，以确保EHSRC研究人员能够最大限度地发挥转化环境健康科学研究的潜力。能够访问ICTS资源以及EHSRC设施对中心研究人员来说是一个很好的机会。我们将通过增强研究设计、IRB支持、测量和生物采样，支持研究者使用这些最先进的设施。和样本分析。此外，我们亦会资助使用资讯及通讯科技设施的费用。爱荷华州ICST大学已经启动了一项对所有研究重新收费的政策。这是根据资金来源分级的，因此行业发起的，行业赞助的试验收取提供服务的实际成本（包括方案审查，文件准备，临床服务等），NIH资助的研究收取折扣费用，通常为50%。因为我们认识到这种费用转移将为新的和没有资金的调查人员提供障碍;为了支持我们的调查人员，我们建议支付其中的很大一部分