Integrative Health Sciences Core

综合健康科学核心

• 批准号: 8279703
• 负责人: Peter S Thorne
• 金额: $ 18.96万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8279703
• 关键词: Acute; Aerosols; Award; Biological; Bronchoscopy; Charge; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Services; Collaborations; Development; Disease; Ensure; Environment; Environmental Exposure; Environmental Health; Exposure to; Fees; Funding; Funding Agency; Gases; Goals; Health; Health Sciences; Human; Image; Industry; Institutes; Institutional Review Boards; Interdisciplinary Study; Investigation; Investments; Iowa; Lung; Measurement; Modality; Monitor; Physiological; Policies; Preparation; Process; Protocols documentation; Pulmonary function tests; Recruitment Activity; Reproducibility; Research; Research Design; Research Infrastructure; Research Personnel; Research Subjects; Resources; Safety; Sampling; Services; Solutions; Specimen; Training; Training and Infrastructure; Translating; Translational Research; United States National Institutes of Health; Universities; cost; cost shifting; discount; experience; exposed human population; health science research; human subject; injured airway; interdisciplinary collaboration; interest; multidisciplinary; patient oriented; research facility; research study; response; response to injury; translational study

9.1.2 Rationale for Goals and Aims The IHSF is a central component of the EHSRC, promoting human-centered research. An emphasis on human studies has been a long-standing strength of the EHSRC; this facility provides the infrastructure to conduct such studies with safety (to both research subjects and investigators), reproducibility, and rigorous scientific approaches. The IHSF supports radiological imaging, bronchoscopies, and other services needed to translate basic investigations into clinical studies. A significant change in the IHSF since our previous application has been driven by the awarding of a Clinical and Translational Science Award (CTSA) to the U.I. ICTS. This development has led to a significant (over $10 million) investment by the University into research infrastructure and facilities from which our EHSRC investigators can benefit. Although the ICST provides outstanding facilities available for human research, its strengths are centered on subject interactions; the IHSF provides support in specific research modalities, including human exposures, enhanced pulmonary function testing, bronchoscopy, and imaging for EHS-related research. We have enhanced the Center services to ensure that EHSRC researchers are able to maximize the potential for translational environmental health science research. Being able to access both ICTS resources as well as EHSRC facilities is a great opportunity for center investigators. We will support investigators using these state-of-the-art facilities by enhanced study design, IRB support, measurements, biological sampling. and specimen analyses. Furthermore, we will subsidize the costs of using the ICTS facilities. The University of Iowa ICST has initiated a policy of recharges for all studies. This is gradated by funding source, so that industry-initiated, industry-sponsored trials are charged the actual cost of providing services (including protocol review, document preparation, clinical services, etc), and NIH-funded studies are charged discounted fees, generally by 50%. Because we recognize that this cost-shifting will provide a barrier for new and non-funded investigators; to support our investigators, we propose to cover a substantial portion of this

9.1.2目标和目标的基本原理 IHSF是EHSRC的核心组成部分，促进了以人为本的研究。对人类研究的重视一直是EHSRC的长期优势。该设施提供了基础设施，以安全性（对研究对象和研究人员），可重复性和严格的科学方法进行此类研究。 IHSF支持放射成像，支气管镜和其他需要将基本研究转化为临床研究所需的服务。 自之前的申请以来，IHSF的重大变化是由授予U.I.的临床和转化科学奖（CTSA）驱动的。 ICT。这一发展导致大学对研究基础设施和设施进行了巨大的投资（超过1000万美元），我们的EHSRC研究人员可以从中受益。尽管ICST为人类研究提供了出色的设施，但其优势集中在主题互动上。 IHSF提供了特定研究方式的支持，包括人类暴露，增强的肺功能测试，支气管镜检查以及与EHS相关研究的成像。我们已经增强了中心服务，以确保EHSRC研究人员能够最大程度地提高转化环境健康科学研究的潜力。能够访问ICT资源以及EHSRC设施，对于中心调查人员来说是一个很好的机会。我们将通过增强研究设计，IRB支持，测量，生物学样本来支持研究人员使用这些最先进的设施。和标本分析。此外，我们将补贴使用ICT设施的成本。爱荷华大学ICST启动了所有研究的补给政策。这是通过资金来源进行评分的，因此，由行业发起的行业赞助的试验收取提供服务的实际成本（包括协议审查，文档准备，临床服务等），而NIH资助的研究收取了折扣费，通常为50％。因为我们认识到这种成本转移将为新的和未资助的调查人员提供障碍；为了支持我们的调查人员，我们建议涵盖其中的很大一部分