17th and 18th International Symposium on Cells of the Hepatic Sinusoid

描述（由申请人提供）：本R13申请申请支持将于2013年9月在日本大阪和2015年9月在俄亥俄州克利夫兰举行的第17届和第18届肝窦细胞国际研讨会（ISCHS）。申请要求支持受邀专家演讲者的参与，以及年轻的临床和基础研究人员。ISCHS的目标是汇集一个国际多学科科学家小组，包括现有的和新的研究人员，以及博士后和博士后学员，他们对共同的问题感兴趣：“肝窦中不同肝细胞类型之间的串扰如何促进肝脏发育和生长、体内平衡和疾病的病理结果？”与会者将在会议上介绍前沿，高质量的研究，开始确定新的分子和细胞相互作用在肝窦。我们对肝脏功能活动的基本单位的理解存在令人惊讶的差距；肝窦细胞生物学的进展对了解酒精性肝病（ALD）的细胞基础至关重要。ISCHS代表了唯一的国际组织，聚集了来自世界各地的肝脏生物学和肝细胞相声的领先研究人员。本次会议将促进和促进：1)患有ALD的不同国家之间的国际合作，2)国际研究人员之间的资源共享，产生协同作用和独特的想法，3)国际层面的学员互动。综上所述，ISCHS的独特环境是一个理想的形式，可以就他们对ALD发病机制的研究的潜在影响进行前沿互动，有助于协同研究，填补这些空白，推进ALD研究的前沿，以及预防和治疗治疗的发展。

DESCRIPTION (provided by applicant): This R13 application requests support for the 17th and 18th International Symposium on Cells of the Hepatic Sinusoid (ISCHS) to be held in Osaka Japan in Sept 2013 and Cleveland OH in Sept 2015. The application requests support for the participation of invited expert speakers, as well as for young clinical and basic investigators. Th goal of the ISCHS is to bring together an international group of multidisciplinary scientists, including established and new investigators, as well as pre- and post-doctoral trainees, who are interested in the common questions: "How does the cross-talk between different liver cell types in the hepatic sinusoid facilitate liver development and growth, homeostasis and pathological outcomes in disease?" Participants at the meeting will present cutting edge, high quality research which begins to identify novel molecular and cellular interactions within the liver sinusoid. There are surprising gaps in our understanding of this basic unit of functional activity n the liver; advances in hepatic sinusoidal cell biology are critical to understanding the cellular basis of alcoholic liver disease (ALD). The ISCHS represents the only international organization which gathers leading investigators in liver biology and hepatocellular cross talk from around the world. This meeting will facilitate and promote: 1) international collaborations between different countries with populations differing in their genetics and social backgrounds who suffer from ALD, 2) resource sharing between international investigators, generating synergy and unique ideas and 3) interaction of trainees at the international level. Taken together, the unique environment of the ISCHS is an ideal format for cutting-edge interactions on the potential implications of their research into the pathogenesis of ALD, helping to synergize research that will fill these gaps and advance the frontier of research in ALD and development of preventative and therapeutic treatments.