Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA)

拉丁裔研究——神经认知老化调查（SOL-INCA）

• 批准号: 9134025
• 负责人: Hector M Gonzalez
• 金额: $ 121.14万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9134025
• 关键词: Accounting; Acculturation; Address; Affect; Age; Aging; Alzheimer' s Disease; American; Americas; Amyloid; Ancillary Study; Area; Blood Vessels; Brain; Cardiovascular Diseases; Caribbean region; Central American; Cohort Studies; Cuban; Data; Dementia; Diabetes Mellitus; Disease; Dominican; Early Intervention; Education; Employee Strikes; Ethnic Origin; Exhibits; Genetic; Genetic Risk; Genotype; Health; Healthcare; Height; Hereditary Disease; Hispanic Community Health Study/Study of Latinos; Hispanics; Intervention; Investigation; Knowledge; Latino; Literature; Methods; Mexican; Mexican Americans; Minority Groups; Neurocognitive; Neurocognitive Deficit; Neurons; Participant; Pattern; Perfusion; Phenotype; Prevalence; Public Health; Puerto Rican; Quality of life; Race; Resources; Risk; Risk Factors; Sampling; South American; Staging; Study of Latinos; Subgroup; Testing; Time; Translating; Variant; Visit; Washington; Work; base; cardiovascular disorder risk; cardiovascular health; cohort; disability; disorder risk; ethnic diversity; ethnic minority population; genetic risk factor; genetic variant; genome-wide; improved; innovation; insight; literacy; low socioeconomic status; meetings; middle age; mild cognitive impairment; mortality; neglect; neurocognitive disorder; neurocognitive test; prevent; socioeconomics

 DESCRIPTION (provided by applicant): Neurocognitive disorders (e.g., Alzheimer's disease) are major public health problems that may disproportionately affect Latinos compared to other Americans. Extant dementia literature from outstanding neuroepidemiologic work indicates that some Latino ancestry groups may have a four-fold increased risk of dementing disorders (e.g., Alzheimer's disease) compared to other Latino groups. The reasons for these striking differences in dementia estimates have not been addressed; represent a major gap in the health scientific literature; and form a major barrier to progress in better understanding dementias among diverse Latino populations. Furthermore, less is known about midlife factors associated with early and pathological neurocognitive deficits and disordrs, regardless of ethnicity/race. Insights from middle-aged and older Latino populations will open new opportunities for mitigating further neurocognitive disorder and related disabilities. Logistically and economically, sampling sufficient numbers of major Latino groups (e.g., Mexicans, Puerto Ricans, Cubans, Dominicans) for well-powered neuroepidemiologic work is prohibitive and forms additional barriers to progress in the field. As an invited Ancillary Study of the Hispanic Community Health Study/Study of Latinos (SOL; n=16,415 at baseline), this proposed project designated as the Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA) would efficiently fill major gaps in the neuroepidemiology Mild Cognitive Impairment/Mild Neurocognitive Disorders (MCI/mNCD). SOL-INCA would examine associations between shared genetic and cardiovascular disease risk factors for neurocognitive deficits and disorders (i.e., MCI/mNCD) among SOL's middle-aged and older Latino subsample (n=9,652 at baseline). Additionally, SOL-INCA would begin to unveil the sociocultural risks and protective factors that may contribute the striking differences in dementia previously found between Latino ancestry groups. SOL-INCA would be integrated into Visit 2 to collect a second time-point of neurocognitive data from returning SOL middle-aged and older Latinos participants (ages 50-80 years old; 2015-2020). We believe that the SOL-INCA approach would enable us to discover behaviorally, culturally appropriate, and biologically plausible targets and means for mitigating early neurocognitive disorders. Our long-term is to translate our findings into actionable means for preventing or delaying milder forms of neurocognitive disorders from evolving into more severe disordered states, especially in Latinos who may be at increased risk for these disorders.

 描述(申请人提供)：神经认知障碍(例如，阿尔茨海默病)是主要的公共卫生问题，与其他美国人相比，拉美裔可能受到不成比例的影响。来自杰出神经流行病学研究的现有痴呆症文献表明，与其他拉丁裔群体相比，一些拉丁裔祖先群体患痴呆症(例如阿尔茨海默病)的风险可能增加四倍。痴呆症估计存在这些显著差异的原因尚未得到解决；是健康科学文献中的一个重大差距；并构成在不同拉丁裔人口中更好地了解痴呆症方面取得进展的主要障碍。此外，对与早期和病理性神经认知缺陷和障碍相关的中年因素知之甚少，无论种族/种族。来自中老年拉丁裔人群的见解将为缓解进一步的神经认知障碍和相关残疾打开新的机会。在后勤和经济上， 对足够数量的主要拉丁裔群体(例如墨西哥人、波多黎各人、古巴人、多米尼克人)进行抽样，以开展强有力的神经流行病学工作，这是令人望而却步的，并对这一领域的进展构成了额外的障碍。作为拉美裔社区健康研究/拉丁裔研究(SOL；基线时n=16,415)的应邀辅助研究，这项拟议的项目被指定为拉丁裔研究--神经认知老化调查(SOL-INCA)，将有效地填补神经流行病学轻度认知障碍/轻度神经认知障碍(MCI/mNCD)方面的主要空白。SOL-INCA将在SOL的中老年拉丁裔亚样本(基线为9,652人)中检查共同的遗传和心血管疾病风险因素与神经认知缺陷和障碍(即MCI/mNCD)之间的关系。此外，Sol-Inca将开始揭示社会文化风险和保护因素，这些风险和保护因素可能导致以前在拉丁裔血统群体之间发现的痴呆症的显著差异。SOL-INCA将被整合到访问2中，以从返回的SOL中老年拉丁裔参与者(年龄50-80岁；2015-2020年)收集第二个时间点的神经认知数据。我们相信，Sol-Inca方法将使我们能够发现行为上、文化上和生物学上合理的目标和方法，以减轻早期神经认知障碍。我们的长期目标是将我们的发现转化为可行的手段，以防止或延缓较轻微形式的神经认知障碍演变为更严重的障碍状态，特别是在可能面临更高风险的拉丁裔人中。