K07 Leadership Grant

描述（由申请人提供）：每年有超过250万美国老年人发生谵妄（急性意识模糊状态），这是一种常见且严重的老年综合征，相关死亡率为25-33%，并在随后的一年中造成> 1000亿美元的医疗保健支出。然而，这些病例中只有不到30%得到确认，得到证实的预防干预措施的更少。解决和预防谵妄的临床护理存在缺陷，因为缺乏经验证据，而且现有证据没有以有效的方式一致地转化。Inouye博士是一位老年病专家和经验丰富的临床研究者，他进行了开创性的工作，以促进我们对谵妄的诊断，风险因素，预后和干预措施的理解。对于这个K 07领导奖，她建议制定全国第一个专门针对老年人谵妄的计划，即“老年谵妄卓越中心：研究，培训和教育增强（CEDARTREE）”，以推进谵妄研究和培训。她将在哈佛医学院-希伯来康复中心建立该项目，汇集临床转化研究、老年医学/老年学领域的世界知名资源以及精湛的跨学科专业知识和资源来支持该项目，这将刺激整个研究大波士顿学术界。具体目标是：1）在谵妄研究中创建一个全面的跨学科培训和导师计划，包括正式的教学课程，研讨会系列，协作工作组和经验丰富的研究人员的个性化导师; 2）开发核心资源，吸引跨学科研究人员参与协作谵妄相关研究（例如，网站研究开发赠款，获得新的研究技术和数据库，研究者列表服务，统计/方法学专业知识，以及谵妄书目）;以及3） 通过传播网站资源和教育内容，主办访问学者计划，年度科学研讨会，国家会议上的利益集团，以及发展国家联系以翻译证据，作为老龄化谵妄研究的地方和国家资源。创新的方法将被纳入该计划的各个层面：谵妄的转化研究（生物标志物，基因组学，先进的神经影像学），先进的统计方法，以解决方法上的挑战，以及创新的教育策略（例如，交互式在线教育方法）。对于Inouye博士来说，K 07奖将为关键领导领域的进一步职业发展提供机会，并保护开发、全面实施、评估、完善和建立自我维持基础设施所需的时间，以确保该中心继续为老龄化研究和培训做出持久贡献。CEDARTREE代表了第一个此类资源，提供了一个创新的和急需的地方/国家资源和协调中心，将提高对老年谵妄的研究能力，最终目标是改善老年人的健康和生活质量。

DESCRIPTION (provided by applicant): Over 2.5 million older Americans develop delirium (acute confusional state) each year, a common and serious geriatric syndrome, with associated mortality rates of 25-33% and accounting for >$100 billion in healthcare expenditures in the ensuing year. Yet, less than 30% of these cases are recognized, and even fewer receive proven preventive interventions. Clinical care to address and prevent delirium is deficient both because empirical evidence is lacking and because existing evidence is not consistently translated in an effective manner. The Candidate, Dr. Inouye, is an expert geriatrician and experienced clinical investigator, who has conducted ground-breaking work to advance our understanding of the diagnosis, risk factors, prognosis, and interventions for delirium. For this K07 Leadership Award, she proposes to develop the nation's first program focusing specifically on delirium in older adults, the "Center of Excellence for Delirium in Aging: Research, Training and Educational Enhancement (CEDARTREE)" to advance delirium research and training. She will establish this program at Harvard Medical School-Hebrew Rehabilitation Center, bringing together world-renowned resources in clinical-translational research, geriatrics/gerontology, and superb interdisciplinary expertise and resources to support the program, which will stimulate research across the greater Boston academic community. The specific aims are to: 1) To create a comprehensive interdisciplinary training and mentorship program in delirium research, including a formal didactic curriculum, seminar series, collaborative working groups, and individualized mentorship with experienced investigators; 2) To develop core resources to attract interdisciplinary investigators to engage in collaborative delirium-related research (e.g., website research development grants, access to novel research technologies and databases, investigator listserve, statistical/methodological expertise, and delirium bibliography); and 3) To serve as a local and national resource for research on delirium in aging through disseminating website resources and educational content, hosting a visiting scholar program, annual scientific symposium, interest groups at national meetings, and developing national linkages to translate evidence. Innovative approaches will be incorporated at every level of the program: translational research on delirium (biomarkers, genomics, advanced neuroimaging), advanced statistical methods to address methodological challenges, and innovative educational strategies (e.g., interactive on-line educational approaches). For Dr. Inouye, the K07 award will provide the opportunity for further career development in key leadership areas and protect time needed to develop, fully implement, evaluate, refine, and establish the self-sustaining infrastructure to assure continuation of the center as an enduring contribution to aging research and training. CEDARTREE represents the first resource of its kind, providing an innovative and much-needed local/national resource and focal point that will enhance the capacity for research on delirium in aging, with the ultimate goal of improving health and quality of life for seniors.