Mapping the Human Connectome During Typical Development

绘制典型发育过程中的人类连接组图

• 批准号: 9331169
• 负责人: SUSAN Y BOOKHEIMER
• 金额: $ 142.32万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-23 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9331169
• 关键词: 15 year old; Adolescence; Adolescent; Adult; Age; Behavior; Behavioral; Biological; Biological Assay; Blood flow; Blood specimen; Brain; Brain imaging; California; Child; Childhood; Cognitive; Communities; Complex; DNA Library; Data; Data Set; Development; Developmental Process; Ethnic Origin; Hair; Health; Hormonal; Hormones; Human; Image; Individual; Knowledge; Longevity; Los Angeles; Magnetic Resonance Imaging; Maps; Measures; Mental disorders; Methods; Minnesota; Modification; Motion; Nature; Participant; Personal Satisfaction; Phase; Pilot Projects; Poverty; Preventive Intervention; Procedures; Process; Property; Protocols documentation; Puberty; Public Health; Race; Research Personnel; Resolution; Resources; Rest; Saliva; Sampling; Scanning; Site; Source; Spin Labels; Structure; Testing; United States National Institutes of Health; Universities; Variant; Washington; adolescent brain development; age related; analytical tool; base; behavior test; computerized data processing; connectome; data acquisition; data sharing; design; early childhood; insight; middle childhood; nervous system disorder; neurodevelopment; neuroimaging; prisma; public health relevance; response; reward processing; sex; success; temporal measurement; tool; young adult

 DESCRIPTION (provided by applicant): The major technological and analytical advances in human brain imaging achieved as part of the Human Connectome Projects (HCP) enable examination of structural and functional brain connectivity at unprecedented levels of spatial and temporal resolution. This information is proving crucial to our understanding of normative variation in adult brain connectivity. It is now timely to use the tools and analytical approaches developed by the HCP to understand how structural and functional wiring of the brain develops. Using state-of-the art HCP imaging approaches will allow investigators to push our currently limited understanding of normative brain development to new levels. This knowledge will critically inform prevention and intervention efforts targeting well known public health concerns (e.g., neurological and psychiatric disorders, poverty). The majority of developmental connectivity studies to date have used fairly coarse resolution, have not been multi-modal in nature, and few studies have used comparable methods to assess individuals across a sufficiently wide age range to truly capture developmental processes (e.g., early childhood through adolescence). Here we propose a consortium of five sites (Harvard, Oxford, UCLA, University of Minnesota, Washington University), with extensive complimentary expertise in brain imaging and neural development, including many of the investigators from the adult and pilot lifespan HCP efforts. Our synergistic integration of advances from the HARVARD-MGH and WU-MINN-OXFORD HCPs with cutting edge expertise in child and adolescent brain development will enable major advances in our understanding of the normative development of human brain connectivity. The resultant unique resource will provide rich, multimodal data on several biological and cognitive constructs that are of critical importance to health and well-being across this age range and allow a wide range of investigators in the community to gain new insights about brain development and connectivity. Aim 1 will be to optimize existing HCP Lifespan Pilot project protocols on the widely available Prisma platform to respect practical constraints in studying healthy children and adolescents over a wide age range and will also collect a matched set of data on the original Skyra and proposed Prisma HCP protocols to serve as a linchpin between the past and present efforts. Aim 2 will be to collect 1500 high quality neuroimaging and associated behavioral datasets on healthy children and adolescents in the age range of 5-21, using matched protocols across sites, enabling robust characterization of age-related changes in network properties including connectivity, network integrity, response properties during tasks, and behavior. Aim 3 will be to collect and analyze longitudinal subsamples, task, and phenotypic measures that constitute intensive sub-studies of inflection points of health-relevant behavioral changes within specific developmental phases. Aim 4 will capitalize on our success in sharing data in the HCP, and use established tools, platforms and procedures to make all data publically available through the Connectome Coordinating Facility (CCF).

 描述(由申请人提供)：作为人类连接组项目(HCP)的一部分，人脑成像方面取得的主要技术和分析进展使我们能够在前所未有的空间和时间分辨率水平上检查大脑的结构和功能连接。事实证明，这一信息对于我们理解成人大脑连接的标准变异至关重要。现在是时候使用HCP开发的工具和分析方法来了解大脑的结构和功能连接是如何发展的了。使用最先进的HCP成像方法将使研究人员将我们目前对标准化大脑发育的有限理解推向新的水平。这些知识将为针对众所周知的公共卫生问题(例如，神经和精神障碍、贫困)的预防和干预工作提供重要信息。到目前为止，大多数发展连通性研究都采用了相当粗略的分辨率，性质上不是多模式的，很少有研究使用可比较的方法来评估足够广泛的年龄段的个人，以真正捕捉发展过程(例如，从幼儿到青春期)。在这里，我们建议一个由五个地点(哈佛大学、牛津大学、加州大学洛杉矶分校、明尼苏达大学、华盛顿大学)组成的联盟，在大脑成像和神经发育方面拥有广泛的免费专业知识，包括许多来自成人和飞行员生命周期HCP努力的研究人员。我们将哈佛-麻省理工学院和吴-明-牛津合作伙伴的进展与儿童和青少年脑发育方面的尖端专业知识协同整合，将使我们在理解人脑连接的规范发展方面取得重大进展。由此产生的独特资源将提供关于几个生物和认知结构的丰富、多模式数据，这些结构对这个年龄段的健康和福祉至关重要，并使社区中的广泛研究人员能够获得关于大脑发育和连接的新见解。目标1将是在广泛可用的PRISMA平台上优化现有的HCP寿命试验项目协议，以尊重在研究广泛年龄范围的健康儿童和青少年方面的实际限制，并将收集关于原始Skyra和拟议的PRISMA HCP协议的一组匹配数据，作为过去和现在工作之间的关键。目标2将收集1500个5-21岁健康儿童和青少年的高质量神经成像和相关行为数据集，使用跨站点的匹配协议，实现对网络属性(包括连接性、网络完整性、任务期间的响应属性和行为)与年龄相关的变化的稳健表征。目标3将收集和分析纵向亚样本、任务和表型测量，这些测量构成对特定发育阶段内与健康相关的行为变化拐点的密集分研究。AIM 4将利用我们在HCP共享数据方面的成功，并使用既定的工具、平台和程序，通过Connectome协调机制(CCF)向公众提供所有数据。