NHP reagent resource for immune-mediated and infectious diseases, and transplantation research

用于免疫介导疾病和传染病以及移植研究的 NHP 试剂资源

• 批准号: 9355557
• 负责人: KEITH A. REIMANN
• 金额: $ 0.83万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-29 至 2016-09-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9355557
• 关键词: Animal Model; Cells; Communicable Diseases; Communities; Contracts; Development; Disease; Evaluation; Goals; Immune; Immune response; Immunologics; In Vitro; Mediating; Modeling; Monitor; Production; Reagent; Research; Resources; Transplantation; in vivo; nonhuman primate

The goal of the Nonhuman Primate (NHP) Reagent Resource is to facilitate and accelerate immunological research in immune-mediated and infectious diseases using this valuable animal model through the development, evaluation, production and distribution of key immunologic reagents to the NHP research community. Reagents covered under this contract include those to 1) monitor or determine the dynamics and parameters of immune responses in vitro and in vivo, 2) deplete select immune cells in vivo, and 3) therapeutically modulate the immune response in vivo. The reagents developed in this project are used in nonhuman primate models to study immune-mediated diseases, infectious diseases, and transplantation.

非人灵长类动物（NHP）试剂资源的目标是通过开发、评估、生产和向NHP研究界分发关键免疫试剂，利用这种有价值的动物模型促进和加速免疫介导和感染性疾病的免疫学研究。本合同涵盖的试剂包括：1）监测或确定体外和体内免疫反应的动力学和参数，2）体内消耗选定的免疫细胞，3）治疗性调节体内免疫反应。本项目开发的试剂用于非人灵长类动物模型，以研究免疫介导的疾病、传染病和移植。