Training Program in Translational Biology and Molecular Medicine

 描述(由申请人提供)：此申请是为了继续支持贝勒医学院(BCM)的翻译生物学和分子医学(TBMM)研究生课程。TBMM项目成立于2004年，基于学院的战略计划，旨在建立新的跨学科项目，推动生物医学研究、临床患者护理和教育一体化的新模式。第一届TBMM班于2005年入学，目前该项目有62名学生和33名毕业生。该项目有200多名参与教师，其中127人的核心小组是目前接受T32培训的教师。跨学科的教员主要在7个临床和8个基础科学系任职，并为T32-受训人员提供各种生物医学研究领域的研究机会。TBMM计划的主要目标是培养生物医学博士科学家在基础和临床研究的交界处工作，并更有效地利用基础和临床研究的成果来改善人类健康。为了实现这一目标，在之前的资助期间，我们继续加强已建立的(现已进入第9个年头)独特的博士课程，采用创新的课程，并由一名基础科学导师和一名临床导师对将生物医学与病理生理学和医学原理相结合的研究项目进行双重指导。虽然我们的成果数据自成立以来仍然很早，但我们的结果数据开始表明，我们已经成功地招募和教育了在基础科学、病理生理学和临床转化研究方面有扎实教育的学生，准备成为在基础医学和临床医学之间进行转化研究的独立调查人员。学生们在各自领域的高影响力期刊上发表他们的论文研究，该项目还通过基础和临床科学导师之间由学生驱动的合作来促进跨学科翻译研究。在我们不断增长的申请者群体和现有学生群体的支持下，我们要求提供总共8个资助职位，比目前的6个资助职位有所增加。在前一个周期这种方法的成功的激励下，我们请求这笔资金再次支持学生 他们在研究生院的第二年和第三年参与临床培训以及从事他们的翻译研究项目。这笔资金将使TBMM项目继续成熟和毕业翻译研究人员，他们开始在学术和非学术职业的翻译研究领域做出改变。它还将使我们能够继续促进和记录基础研究人员和临床研究人员之间有效互动的方式，并成功培养新型博士研究生，以满足国家对领导未来转化性研究工作的需求。

 DESCRIPTION (provided by applicant): This application is for continued support of the Translational Biology and Molecular Medicine (TBMM) graduate program at Baylor College of Medicine (BCM). The TBMM program was founded in 2004 based on the strategic plan of the College to establish new interdisciplinary programs that will drive a new model of integration of biomedical research, clinical patient care and education. The first TBMM class matriculated in 2005 and there are currently 62 students in the program and 33 total graduates. The program counts over 200 participating faculty, of which a core group of 127 are current T32-training faculty. The interdisciplinary faculty members have their primary appointments in 7 clinical and 8 basic science departments and offer research opportunities to T32-trainees in a variety of translational biomedical research areas. The major goal of the TBMM program is to train biomedical PhD scientists to work at the interface of basic and clinical research and more effectively exploit the findings of basic and clinical research to improve human health. To achieve this goal, we have during the prior funding period continue to enhance an established (now in its 9th year) unique PhD program with an innovative curriculum and dual mentorship by a basic science mentor and a clinical mentor of research projects that incorporate biomedical sciences with pathophysiology and medical principles. Although still early since inception, our outcomes data begin to show that we have been successful in recruiting and educating students who graduate with a solid education in basic science, pathophysiology and clinical translational research, prepared to become independent investigators performing translational research at the interface between basic and clinical medicine. Students publish their thesis research in high-impact journals in their respective areas and the program is also promoting interdisciplinary translational research through student-driven collaborations between basic and clinical science mentors. Supported by our growing applicant pool and current student body, we are requesting a total of eight funded positions, an increase from our 6 currently funded positions. Motivated by success of this approach in the prior cycle, we request this funding will again support students in their second and third years of graduate school when they are involved in clinical training as well as pursuing their translational research projects. This funding will allow the TBMM program to continue to mature and graduate translational researchers, who are beginning to make a difference in the field of translational research in academic and non-academic careers. It will also allow us to continue to promote and document ways of effective interaction between basic and clinical investigators and to successfully train a new type of PhD graduate to fill the nationa need to lead future translational research efforts.