Training Program in Translational Biology and Molecular Medicine

 描述（由申请人提供）：本申请是为了继续支持贝勒医学院的转化生物学和分子医学（TBMM）研究生课程。TBMM计划成立于2004年，基于学院的战略计划，建立新的跨学科计划，这将推动生物医学研究，临床患者护理和教育的整合新模式。第一个TBMM班于2005年入学，目前有62名学生在该方案和33名毕业生。该计划有200多名参与教师，其中127名核心小组是目前的T32培训教师。跨学科的教师在7个临床和8个基础科学部门有他们的主要任命，并提供研究机会，以T32-学员在各种转化生物医学研究领域。TBMM计划的主要目标是培养生物医学博士科学家在基础和临床研究的接口工作，并更有效地利用基础和临床研究的结果，以改善人类健康。为了实现这一目标，我们在前一个资助期内继续加强一个既定的（现在是第9年）独特的博士课程，该课程具有创新的课程和基础科学导师和临床导师的双重导师制，这些导师将生物医学科学与病理生理学和医学原理相结合。虽然自成立以来仍处于早期阶段，但我们的结果数据开始表明，我们已经成功地招募和教育了在基础科学，病理生理学和临床转化研究方面具有扎实教育的毕业生，准备成为在基础和临床医学之间进行转化研究的独立研究者。学生在各自领域的高影响力期刊上发表论文研究，该计划还通过学生驱动的基础和临床科学导师之间的合作促进跨学科转化研究。在我们不断增长的申请人和现有学生群体的支持下，我们共申请了8个资助职位，比我们目前的6个资助职位有所增加。由于这种方法在上一个周期的成功，我们要求这笔资金将再次支持学生， 他们在研究生院的第二和第三年，当他们参与临床培训以及追求他们的转化研究项目。这笔资金将使TBMM计划能够继续成熟和毕业的翻译研究人员，他们开始在学术和非学术职业的翻译研究领域发挥作用。它还将使我们能够继续促进和记录基础和临床研究人员之间有效互动的方式，并成功培养新型博士毕业生，以满足国家领导未来转化研究工作的需求。

 DESCRIPTION (provided by applicant): This application is for continued support of the Translational Biology and Molecular Medicine (TBMM) graduate program at Baylor College of Medicine (BCM). The TBMM program was founded in 2004 based on the strategic plan of the College to establish new interdisciplinary programs that will drive a new model of integration of biomedical research, clinical patient care and education. The first TBMM class matriculated in 2005 and there are currently 62 students in the program and 33 total graduates. The program counts over 200 participating faculty, of which a core group of 127 are current T32-training faculty. The interdisciplinary faculty members have their primary appointments in 7 clinical and 8 basic science departments and offer research opportunities to T32-trainees in a variety of translational biomedical research areas. The major goal of the TBMM program is to train biomedical PhD scientists to work at the interface of basic and clinical research and more effectively exploit the findings of basic and clinical research to improve human health. To achieve this goal, we have during the prior funding period continue to enhance an established (now in its 9th year) unique PhD program with an innovative curriculum and dual mentorship by a basic science mentor and a clinical mentor of research projects that incorporate biomedical sciences with pathophysiology and medical principles. Although still early since inception, our outcomes data begin to show that we have been successful in recruiting and educating students who graduate with a solid education in basic science, pathophysiology and clinical translational research, prepared to become independent investigators performing translational research at the interface between basic and clinical medicine. Students publish their thesis research in high-impact journals in their respective areas and the program is also promoting interdisciplinary translational research through student-driven collaborations between basic and clinical science mentors. Supported by our growing applicant pool and current student body, we are requesting a total of eight funded positions, an increase from our 6 currently funded positions. Motivated by success of this approach in the prior cycle, we request this funding will again support students in their second and third years of graduate school when they are involved in clinical training as well as pursuing their translational research projects. This funding will allow the TBMM program to continue to mature and graduate translational researchers, who are beginning to make a difference in the field of translational research in academic and non-academic careers. It will also allow us to continue to promote and document ways of effective interaction between basic and clinical investigators and to successfully train a new type of PhD graduate to fill the nationa need to lead future translational research efforts.