Translational Research in Hypertension and Renal Biology

由于高血压及相关的肾脏和心血管疾病在路易斯安那州非常普遍，杜兰健康科学中心建立了高血压和肾脏卓越中心，由于科布尔奖的大力支持，该中心得到了迅速发展。Cobre第一阶段和第二阶段为16名初级教员提供了支持，其中7名获得了NIH的研究资金，19名博士后研究员，12名研究生和29名医学生。此外，分子、成像和分析核心显著加强了研究基础设施，拥有最先进的设施，以及为高血压和肾脏中心成员服务的转基因动物核心。对于第三阶段，长期目标是为所有研究人员提供一个丰富的环境，以便他们能够保持全国竞争地位，并增强和加强杜兰大学研究人员在高血压、肾脏和心血管疾病方面的生物医学研究能力和基础设施。我们的长期目标将通过以下目标实现：1)为维护在第一阶段和第二阶段开发的Cobre研究核心提供支持，这些核心对于继续该中心的基础、临床和转化性研究至关重要。2)加强杜兰健康科学中心在高血压、肾脏和血管生物学多学科领域的研究基础设施，从而保持和提高NIH的国家竞争力和我们的教员研究人员提供的其他联邦拨款。3)在杜兰健康科学中心鼓励和促进基础科学研究人员和高血压及相关领域的临床翻译科学家之间的协作互动。4)通过为研究试点项目以及指导和培训部分提供支持，维持协作的多学科研究环境。 总体而言，这些结果将有助于加深对导致高血压及相关肾脏和心血管疾病的病理生理紊乱的多重相互作用的理解。科布雷将继续增加在该地区具有极高生物医学相关性的疾病特定领域具有竞争力的科学家的数量。

Because hypertension and associated kidney & cardiovascular diseases are highly prevalent in Louisiana, Tulane Health Sciences Center established a Hypertension and Renal Center of Excellence, which has developed rapidly as a consequence of the substantial support received by the COBRE award. COBRE Phases I and II provided support for 16 junior faculty members, of which 7 received NIH research funding, 19 postdoctoral fellows, 12 graduate students, and 29 medical students. In addition, the research infrastructure was markedly enhanced by the Molecular, Imaging, and Analytical Core, with state-of-the art facilities, and Transgenic Animal Core serving members of the Hypertension and Renal Center. For Phase III, the long-term goals are to provide an enriched environment to all investigators so that they can maintain nationally competitive status and to augment and strengthen the biomedical research capacity and infrastructure for Tulane investigators in hypertension, renal and cardiovascular disease. Our long term goals will be achieved through the following aims: 1) To provide support for maintaining the COBRE research CORES developed during Phases I and II that are essential for continuing the center's basic, clinical, and translational research. 2) To enhance the research infrastructure at Tulane Health Sciences Center in the multidisciplinary area of hypertension, renal and vascular biology thus maintaining and increasing national competitiveness for NIH and other federal grants by our faculty investigators. 3) To encourage and facilitate collaborative interactions between basic science investigators and clinical translational scientists in hypertension and related areas at Tulane Health Sciences Center. 4) To sustain a collaborative multidisciplinary research environment by providing support for research pilot projects and mentoring and training components. Collectively, the results will contribute to an increased understanding of the multiple interaction leading to the pathophysiological derangements that lead to hypertension and associated kidney and cardiovascular diseases. This COBRE will continue to increase the number of competitive scientists in a disease specific area of extremely high biomedical relevance in this region.