New Faculty Recruitment to Enhance Resources in Hypertension Research

招募新教师以增强高血压研究资源

• 批准号: 7936120
• 负责人: Luis Gabriel Navar
• 金额: $ 65.59万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7936120
• 关键词: Address; Angiotensin I; Angiotensin II; Angiotensinogen; Angiotensins; Animals; Apoptosis; Applications Grants; Appointment; Area; Arts; Awareness; Basic Science; Biomedical Research; Blood Pressure; Cardiovascular Diseases; Cardiovascular system; Chronic; Clinical; Complex; Core Facility; Development; Disease; Doctor of Philosophy; Environment; Enzyme Inhibition; Equipment; Evaluation; Experimental Designs; Faculty; Fostering; Functional RNA; Funding; Future; Generations; Genes; Goals; Heart Hypertrophy; Homeostasis; Hormones; Housing; Human; Hypertension; Immunology; Inflammation; Infusion procedures; Injury; Institution; International; Kidney; Kidney Diseases; Knockout Mice; Lead; Liquid substance; Louisiana; Mediating; Mediator of activation protein; MicroRNAs; Mission; Modeling; Molecular; Monitor; Morphology; Mus; Nursing Faculty; Paper; Patient Care; Peptidyl-Dipeptidase A; Phenotype; Physiology; Pilot Projects; Play; Postdoctoral Fellow; Public Health Schools; Qualifying; Renal Hypertension; Renal function; Renin; Renin-Angiotensin System; Reporting; Repression; Research; Research Activity; Research Infrastructure; Research Personnel; Resources; Role; Scientific Societies; Sodium; Tissues; Training; Tropical Medicine; United States National Institutes of Health; Universities; Water; base; blood pressure regulation; enzyme activity; enzyme substrate; experience; improved; medical schools; meetings; member; multidisciplinary; planetary Atmosphere; post-doctoral training; prevent; professor; programs; public education; research study

DESCRIPTION (provided by applicant): The mission of the Tulane Hypertension and Renal Center of Excellence (THRCE) is to stimulate research activities related to cardiovascular, kidney, and hypertension related diseases and is a multidisciplinary Center with members from clinical and basic science departments. This application proposes to augment and expand biomedical research efforts in the area of cardiovascular and hypertension related diseases by hiring one newly independent investigator (Nil) and providing a start-up package and all resources and support needed for the Nil to develop a competitive research program. We propose to appoint Romer A. Gonzalez-Villalobos, MD, PhD, a postdoctoral fellow, as a tenure track assistant professor in the Department of Physiology. With this plan, the center seeks to provide the new faculty with an enriched environment, and enhance the center's research resources by creating a new core for cardiovascular and renal mouse phenotyping. In this regard Dr. Gonzalez is uniquely qualified to perform phenotyping studies in mice by virtue of his academic background, experience and technical training. For the pilot project Dr. Gonzalez- Villalobos has formulated the hypothesis that during Ang ll-induced hypertension, intrarenal ACE-derived Ang II formation is required in order to augment Ang II levels in the kidney that in turn increase sodium and water retention, increase miR-21 expression, and lead to the progressive development of high blood pressure and renal injury. Experiments will be performed in tissue-specific ACE knockout mice in order to address this hypothesis. The plan for fostering and monitoring the NIl includes providing the candidate with the requisite infrastructure, equipment and technical support; establishing an atmosphere conducive to a strong collaborative network; providing a forum for critical evaluation of experimental design, results, papers and grant proposals; and encouraging the candidate's attendance and participation in national and international meetings as well as involvement in scientific societies and active pursuit of funding. The proposed plan will provide the means to develop and support the new faculty in his quest to improve our understanding of the mechanisms participating in angiotensin II synthesis in the kidneys and its role in the development of hypertension. This is important because angiotensin II is a hormone that plays a major role in the control of renal function, the development of hypertension and kidney damage.

描述（由申请人提供）：杜兰高血压和肾脏卓越中心（THRCE）的使命是促进心血管、肾脏和高血压相关疾病的研究活动，是一个多学科中心，成员来自临床和基础科学部门。该申请旨在通过聘请一名新的独立研究员（Nil）并提供启动包以及Nil开发有竞争力的研究计划所需的所有资源和支持来增强和扩大心血管和高血压相关疾病领域的生物医学研究工作。我们建议任命罗默A. Gonzalez-Villalobos，医学博士，博士，博士后研究员，生理学系终身助理教授。通过这一计划，该中心旨在为新的教师提供一个丰富的环境，并通过创建心血管和肾脏小鼠表型的新核心来增强该中心的研究资源。在这方面，Gonzalez博士凭借其学术背景、经验和技术培训，具有在小鼠中进行表型研究的独特资格。对于试点项目，Gonzalez-Villalobos博士提出了这样的假设，即在Ang II诱导的高血压期间，需要肾内ACE衍生的Ang II形成以增加肾脏中的Ang II水平，这反过来增加钠和水潴留，增加miR-21表达，并导致高血压和肾损伤的进行性发展。将在组织特异性ACE敲除小鼠中进行实验，以解决该假设。促进和监测国家实验室的计划包括：为候选人提供必要的基础设施、设备和技术支持;建立一个有利于建立强有力的合作网络的氛围;提供一个论坛，对实验设计、结果、论文和赠款提案进行严格评估;并鼓励候选人出席和参加国家和国际会议以及参与科学协会，积极争取资金。 拟议的计划将提供发展和支持新教师的手段，以提高我们对参与肾脏血管紧张素II合成的机制及其在高血压发展中的作用的理解。这一点很重要，因为血管紧张素II是一种在控制肾功能、高血压和肾损伤的发展中起主要作用的激素。