Rush Alzheimer's Disease Core Center

拉什阿尔茨海默病核心中心

• 批准号: 9172117
• 负责人: DAVID ALAN BENNETT
• 金额: $ 270.03万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-15 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9172117
• 关键词: Aging; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s Disease Core Center; Area; Autopsy; Biochemical; Biological Markers; Brain; Cessation of life; Clergy; Clinical; Cohort Studies; Communities; Data; Data Collection; Data Set; Dementia; Diagnosis; Elderly; Enrollment; Environment; Ethnic Origin; Etiology; Evaluation; Exercise; Funding; Genomics; Goals; Impaired cognition; Institution; Latino; Leadership; Link; Measures; Medical; Mentorship; Methodology; Molecular; Motor; Parkinsonian Disorders; Participant; Pathogenesis; Pathologic; Pathology; Performance; Peripheral; Persons; Pilot Projects; Prevention; Procedures; Process; Proteomics; Race; Religion and Spirituality; Research; Research Infrastructure; Research Personnel; Research Priority; Resource Sharing; Resources; Risk Factors; Source; Specimen; Staging; Structure; Systems Biology; Techniques; Translational Research; Trust; Universities; Work; brain tissue; community based participatory research; data management; design; drug discovery; education research; epigenomics; ethnic minority population; follow-up; health disparity; indexing; innovation; member; metabolomics; mild cognitive impairment; neuroimaging; neuropathology; new therapeutic target; normal aging; operation; outreach; programs; psychologic; public health priorities; racial minority; relational database; transcriptomics

ABSTRACT - OVERVIEW The overall goal of the proposed renewal of the Rush Alzheimer’s Disease Core Center (Rush ADCC) is to continue to support the performance of cutting edge and innovative research on the etiology, pathogenesis, diagnosis, treatment, and prevention of MCI, AD, and other common dementias, by providing researchers with a stimulating multi-disciplinary environment, and unique and highly valued clinical and post-mortem data, and ante- and post-mortem biologic specimens. The Rush ADCC has been in continuous operation since 1991. It has eight Cores carefully designed to support a variety of timely and important areas of research including studies: 1) of the transition from normal aging to MCI and to the earliest stages of dementia with substantial participation by racial and ethnic minorities, 2) linking risk factors to normal aging, incident MCI and incident AD, and to post-mortem indices of AD and mixed pathologies, 3) that incorporate contemporary high throughput biochemical and molecular data into clinical-pathologic cohort studies, and 4) that link neuroimaging and biofluid biomarkers to contemporary biochemical and molecular data, 5) that support drug discovery pipelines, and 6) that support studies of impaired motor function. The Administrative Core will provide scientific leadership to the ADCC as a whole. The Clinical Core will collect UDS and additional data on Blacks without dementia and work to obtain brain autopsy. The Religious Orders Study (ROS) Core will follow older members of Catholic religious communities who have agreed to annual evaluation and brain donation at death. The Latino Core will collect the same data as in ROS on older Latinos without dementia and work to obtain brain autopsy. The Neuropathology Core will process, store, evaluate and distribute biospecimens obtained by the Clinical, ROS, and Latino Cores. The Outreach and Recruitment Core will provide a wide range of educational programs to support outreach and recruitment of racial and ethnic minorities into the Clinical and Latino Cores, and other NIA funded initiatives. The Data Management and Statistical Core will continue to provide the infrastructure that allows all other Cores to be maximally successful and impactful, and will provide statistical support to users of ADCC resources especially junior investigators and trainees. The new Research and Education Component will provide a structured program of mentorship across the ADCC, Rush University of the Rush ADCC strategic partners.

摘要-概述 拉什阿尔茨海默病核心中心（Rush ADCC）的拟议更新的总体目标是 继续支持对病因学，发病机制， 诊断，治疗和预防MCI，AD和其他常见痴呆症，通过为研究人员提供 一个刺激的多学科环境，独特的和高度重视的临床和尸检数据， 生前和死后的生物样本。Rush ADCC自1991年以来一直在持续运营。它 有八个核心精心设计，以支持各种及时和重要的研究领域，包括 研究：1）从正常衰老到MCI和痴呆的早期阶段的过渡， 种族和少数民族的参与，2）将风险因素与正常衰老、MCI事件和 AD，以及AD和混合病理的尸检指数，3）结合当代高 将生物化学和分子数据纳入临床病理学队列研究，以及4）将 神经成像和生物流体生物标志物与当代生物化学和分子数据，5）支持药物 发现管道，以及6）支持受损运动功能的研究。 行政核心将为整个ADCC提供科学领导。临床核心将收集 UDS和其他关于没有痴呆症的黑人的数据，并努力获得大脑尸检。的宗教命令 研究（ROS）核心将跟踪天主教宗教社区的老年成员，他们同意每年参加一次 评估和死后大脑捐赠拉丁裔核心将收集与ROS中老年拉丁裔相同的数据 没有痴呆症并进行脑部解剖神经病理学核心将处理，存储，评估 并分发临床、ROS和拉丁裔核心获得的生物标本。外展和招聘 核心将提供广泛的教育计划，以支持外展和招募种族和 少数民族进入临床和拉丁美洲核心，以及其他NIA资助的倡议。数据管理 统计核心将继续提供基础设施，使所有其他核心能够最大限度地 成功和有影响力，并将为ADCC资源的用户，特别是初级用户提供统计支持 调查员和学员。新的研究和教育部分将提供一个结构化的方案， 导师横跨ADCC，拉什大学是拉什ADCC的战略合作伙伴。