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Conduct of studies to evaluate the toxic and carcinogenic potential of naturally occurring asbestos in laboratory animals for the National Toxicology Program (NTP)

Conduct of studies to evaluate the toxic and carcinogenic potential of naturally occurring asbestos in laboratory animals for the National Toxicology Program (NTP)
为国家毒理学计划 (NTP) 开展研究，评估实验动物中天然存在的石棉的毒性和致癌潜力
批准号：
9263739
负责人：
BARNEY SPARROW
金额：
$50.0万
依托单位：
BATTELLE MEMORIAL INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
项目状态：
已结题
起止时间：
2014-04-15 至 2017-04-14
来源：
https://reporter.nih.gov/project-details/9263739
关键词：
AnimalsAsbestosBreathingChemicalsDataDoseFiberGoalsHistopathologyHumanInhalation ExposureLaboratory AnimalsMethodsNational Toxicology ProgramPreparationResearch DesignRiskTissuesToxic effectToxicity TestsWorkcarcinogenicitydesignhazardmethod developmentresponse

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英文摘要
The goal of this project is to develop inhalation exposure, tissue burden preparation and analysis methods and histopathology methods to facilitate the NTPs designing of toxicity and carcinogenicity studies of naturally occurring asbestos. There is a need to generate high quality, dose response data on different types of asbestos fibers. However, there are numerous methodological challenges that need to be resolved prior to finalization of the design of these studies. Method development work is currently in progress. Keywords: toxicity, carcinogenicity, asbestos, inhalation, fiber
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