Conduct of studies to evaluate the toxic and carcinogenic potential of naturally occurring asbestos in laboratory animals for the National Toxicology Program (NTP)

为国家毒理学计划 (NTP) 开展研究，评估实验动物中天然存在的石棉的毒性和致癌潜力

• 批准号: 9263739
• 负责人: BARNEY SPARROW
• 金额: $ 50万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2017-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9263739
• 关键词: Animals; Asbestos; Breathing; Chemicals; Data; Dose; Fiber; Goals; Histopathology; Human; Inhalation Exposure; Laboratory Animals; Methods; National Toxicology Program; Preparation; Research Design; Risk; Tissues; Toxic effect; Toxicity Tests; Work; carcinogenicity; design; hazard; method development; response

The goal of this project is to develop inhalation exposure, tissue burden preparation and analysis methods and histopathology methods to facilitate the NTPs designing of toxicity and carcinogenicity studies of naturally occurring asbestos. There is a need to generate high quality, dose response data on different types of asbestos fibers. However, there are numerous methodological challenges that need to be resolved prior to finalization of the design of these studies. Method development work is currently in progress. Keywords: toxicity, carcinogenicity, asbestos, inhalation, fiber

本项目的目标是开发吸入暴露、组织负荷制备和分析方法以及组织病理学方法，以促进天然石棉毒性和致癌性研究的NTP设计。有必要就不同类型的石棉纤维生成高质量的剂量反应数据。然而，在最后确定这些研究的设计之前，需要解决许多方法上的挑战。方法开发工作目前正在进行中。 关键词：毒性，致癌性，石棉，吸入，纤维