Perforinopathy: Immune-disease due to defective perforin function
Perforinopathy: Immune-disease due to defective perforin function
批准号:
nhmrc : 1062706
负责人:
A/Pr Ilia Voskoboinik
金额:
$44.78万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2016-12-31
中文摘要
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英文摘要
White blood cells called cytotoxic lymphocytes destroy cancerous cells using special toxic molecules. One of them, perforin, eliminates dangerous cells by punching holes in their membrane. Some individuals that lack perforin become seriously ill in their infancy. Others, that retain some perforin in their lymphocytes can live longer and are at higher risk of developing cancer. We will investigate the causes of partial loss of perforin function and explore novel drug therapies, which should address the problem and restore immune function.
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会议论文
Novel therapies to enhance anti-tumour immunity
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批准号:nhmrc : GNT1139626
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项目类别:Project Grants
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资助金额:$79.76万
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财政年份:2018
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负责人:A/Pr Ilia Voskoboinik
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依托单位:
Novel therapies to enhance anti-tumour immunity
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批准号:nhmrc : 1139626
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项目类别:Project Grants
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资助金额:$53.93万
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财政年份:2018
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负责人:A/Pr Ilia Voskoboinik
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依托单位:
The biogenesis of cytotoxic granules
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批准号:nhmrc : GNT1128587
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项目类别:Project Grants
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资助金额:$82.46万
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财政年份:2017
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负责人:A/Pr Ilia Voskoboinik
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依托单位:
The biogenesis of cytotoxic granules
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批准号:nhmrc : 1128587
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项目类别:Project Grants
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资助金额:$56.33万
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财政年份:2017
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负责人:A/Pr Ilia Voskoboinik
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依托单位:
Structural studies on the immune effector perforin: developing mechanism-based inhibitors
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批准号:nhmrc : 1100478
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项目类别:Project Grants
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资助金额:$76.72万
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财政年份:2016
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负责人:A/Pr Ilia Voskoboinik
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依托单位:
Structural studies on the immune effector perforin: developing mechanism-based inhibitors
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批准号:nhmrc : GNT1100478
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项目类别:Project Grants
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资助金额:$111.66万
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财政年份:2016
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负责人:A/Pr Ilia Voskoboinik
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依托单位:
How the immune system controls viral infections and cancer
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批准号:nhmrc : GNT1059126
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项目类别:Research Fellowships
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资助金额:$60.14万
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财政年份:2014
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负责人:A/Pr Ilia Voskoboinik
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依托单位:
Regulation and mechanisms of cytotoxic lymphocyte function
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批准号:nhmrc : 1059126
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项目类别:Research Fellowships
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资助金额:$42.08万
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财政年份:2014
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负责人:A/Pr Ilia Voskoboinik
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依托单位:
Dissecting a Serial Killer: Investigating the Degranulation Pathways in Cytotoxic Lymphocytes
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批准号:nhmrc : 1062990
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项目类别:Project Grants
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资助金额:$40.31万
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财政年份:2014
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负责人:A/Pr Ilia Voskoboinik
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依托单位:
Uncovering Perforin Secrets
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批准号:nhmrc : 1029295
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项目类别:Project Grants
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资助金额:$41.31万
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财政年份:2012
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负责人:A/Pr Ilia Voskoboinik
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依托单位:
Structural, Biochemical and Biophysical Studies on Perforin
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批准号:nhmrc : 606557
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项目类别:NHMRC Project Grants
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资助金额:$58.46万
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财政年份:2010
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负责人:A/Pr Ilia Voskoboinik
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依托单位:
Regulation of perforin function and implications for disease
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批准号:nhmrc : 628485
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项目类别:Career Development Fellowships
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资助金额:$29.09万
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财政年份:2010
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负责人:A/Pr Ilia Voskoboinik
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依托单位:
Molecular and cellular mechanisms of cytotoxic lymphocyte perforin
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批准号:nhmrc : 566583
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项目类别:NHMRC Project Grants
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资助金额:$27.95万
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财政年份:2009
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负责人:A/Pr Ilia Voskoboinik
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依托单位:
Mechanisms and function of perforin, A key regulator of immune homoeostasis
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批准号:nhmrc : 454787
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项目类别:Career Development Fellowships
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资助金额:$26.52万
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财政年份:2007
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负责人:A/Pr Ilia Voskoboinik
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依托单位:
Mechanism and regulation of perforin function
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批准号:nhmrc : 400041
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项目类别:NHMRC Project Grants
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资助金额:$29.35万
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财政年份:2006
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负责人:A/Pr Ilia Voskoboinik
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依托单位:
海外基金