The biogenesis of cytotoxic granules

细胞毒性颗粒的生物发生

• 批准号: nhmrc : GNT1128587
• 负责人: A/Pr Ilia Voskoboinik
• 金额: $ 82.46万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/biogenesis-cytotoxic-granules/1347703
• 关键词: biogenesis; cytotoxic; granules

Cytotoxic lymphocytes are immune cells responsible for the killing infected or cancerous cells. How cytotoxic lymphocytes mature from a naive inactive to a fully activated state as they encounter infected or malignant cells is poorly understood, and will be investigated in the current proposal. Our results will aid in the development of novel therapies for cancer and other immunological diseases.

细胞毒性淋巴细胞是负责杀死感染细胞或癌细胞的免疫细胞。当细胞毒性淋巴细胞遇到感染或恶性细胞时，细胞毒性淋巴细胞如何从幼稚的非活性状态成熟为完全活化状态，目前尚不清楚，将在本提案中进行研究。我们的研究结果将有助于开发癌症和其他免疫性疾病的新疗法。