Structural studies on the immune effector perforin: developing mechanism-based inhibitors

免疫效应器穿孔素的结构研究：开发基于机制的抑制剂

• 批准号: nhmrc : 1100478
• 负责人: A/Pr Ilia Voskoboinik
• 金额: $ 76.72万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-studies-immune-based-inhibitors/662515
• 关键词: Structural; studies; immune; effector; perforin

Perforin is an essential weapon deployed by the human immune cells in order to destroy virally infected or cancerous cells. Despite this key role, unwanted or excessive perforin function can result in disease and can severely impact on successful treatment of leukaemia through bone marrow transplantation. This application aims to understand the molecular details of perforin function, and to apply this knowledge to develop perforin inhibitors.

穿孔素是人类免疫细胞用来摧毁病毒感染或癌细胞的重要武器。尽管发挥了这一关键作用，但不受欢迎的或过度的穿孔素功能可能会导致疾病，并可能严重影响通过骨髓移植成功治疗白血病。本应用旨在了解穿孔素功能的分子细节，并将这一知识应用于开发穿孔素抑制剂。