Structural, Biochemical and Biophysical Studies on Perforin

穿孔素的结构、生化和生物物理研究

• 批准号: nhmrc : 606557
• 负责人: A/Pr Ilia Voskoboinik
• 金额: $ 58.46万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-biochemical-biophysical-studies-perforin/97572
• 关键词: Structural; Biochemical; Biophysical; Studies; Perforin

This proposal focuses upon understanding the structure and mechanism of perforin, a protein that performs a crucial role in human immunity. We will investigate how certain mutations in perforin cause deficiency and disease. Our work will also seek to understand how potential therapeutics act to modulate perforin function. Finally, through a combination of biochemical and structural studies we will elucidate the details of perforin mechanism.

这项建议侧重于了解穿孔素的结构和机制，穿孔素是一种在人类免疫中发挥关键作用的蛋白质。我们将研究穿孔素的某些突变是如何导致缺陷和疾病的。我们的工作还将试图了解潜在的治疗方法如何作用于调节穿孔素功能。最后，通过生化和结构研究相结合的方法，我们将阐明穿孔素的详细机制。