Structural, Biochemical and Biophysical Studies on Perforin
Structural, Biochemical and Biophysical Studies on Perforin
批准号:
nhmrc : 606557
负责人:
A/Pr Ilia Voskoboinik
金额:
$58.46万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-01 至 2013-12-31
中文摘要
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英文摘要
This proposal focuses upon understanding the structure and mechanism of perforin, a protein that performs a crucial role in human immunity. We will investigate how certain mutations in perforin cause deficiency and disease. Our work will also seek to understand how potential therapeutics act to modulate perforin function. Finally, through a combination of biochemical and structural studies we will elucidate the details of perforin mechanism.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Novel therapies to enhance anti-tumour immunity
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批准号:nhmrc : GNT1139626
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项目类别:Project Grants
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资助金额:$79.76万
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财政年份:2018
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负责人:A/Pr Ilia Voskoboinik
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依托单位:
Novel therapies to enhance anti-tumour immunity
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批准号:nhmrc : 1139626
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项目类别:Project Grants
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资助金额:$53.93万
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财政年份:2018
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负责人:A/Pr Ilia Voskoboinik
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依托单位:
The biogenesis of cytotoxic granules
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批准号:nhmrc : GNT1128587
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项目类别:Project Grants
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资助金额:$82.46万
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财政年份:2017
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负责人:A/Pr Ilia Voskoboinik
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依托单位:
The biogenesis of cytotoxic granules
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批准号:nhmrc : 1128587
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项目类别:Project Grants
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资助金额:$56.33万
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财政年份:2017
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负责人:A/Pr Ilia Voskoboinik
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依托单位:
Structural studies on the immune effector perforin: developing mechanism-based inhibitors
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批准号:nhmrc : 1100478
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项目类别:Project Grants
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资助金额:$76.72万
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财政年份:2016
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负责人:A/Pr Ilia Voskoboinik
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依托单位:
Structural studies on the immune effector perforin: developing mechanism-based inhibitors
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批准号:nhmrc : GNT1100478
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项目类别:Project Grants
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资助金额:$111.66万
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财政年份:2016
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负责人:A/Pr Ilia Voskoboinik
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依托单位:
How the immune system controls viral infections and cancer
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批准号:nhmrc : GNT1059126
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项目类别:Research Fellowships
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资助金额:$60.14万
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财政年份:2014
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负责人:A/Pr Ilia Voskoboinik
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依托单位:
Perforinopathy: Immune-disease due to defective perforin function
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批准号:nhmrc : 1062706
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项目类别:Project Grants
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资助金额:$44.78万
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财政年份:2014
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负责人:A/Pr Ilia Voskoboinik
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依托单位:
Regulation and mechanisms of cytotoxic lymphocyte function
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批准号:nhmrc : 1059126
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项目类别:Research Fellowships
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资助金额:$42.08万
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财政年份:2014
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负责人:A/Pr Ilia Voskoboinik
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依托单位:
Dissecting a Serial Killer: Investigating the Degranulation Pathways in Cytotoxic Lymphocytes
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批准号:nhmrc : 1062990
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项目类别:Project Grants
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资助金额:$40.31万
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财政年份:2014
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负责人:A/Pr Ilia Voskoboinik
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依托单位:
Uncovering Perforin Secrets
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批准号:nhmrc : 1029295
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项目类别:Project Grants
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资助金额:$41.31万
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财政年份:2012
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负责人:A/Pr Ilia Voskoboinik
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依托单位:
Regulation of perforin function and implications for disease
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批准号:nhmrc : 628485
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项目类别:Career Development Fellowships
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资助金额:$29.09万
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财政年份:2010
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负责人:A/Pr Ilia Voskoboinik
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依托单位:
Molecular and cellular mechanisms of cytotoxic lymphocyte perforin
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批准号:nhmrc : 566583
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项目类别:NHMRC Project Grants
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资助金额:$27.95万
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财政年份:2009
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负责人:A/Pr Ilia Voskoboinik
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依托单位:
Mechanisms and function of perforin, A key regulator of immune homoeostasis
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批准号:nhmrc : 454787
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项目类别:Career Development Fellowships
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资助金额:$26.52万
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财政年份:2007
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负责人:A/Pr Ilia Voskoboinik
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依托单位:
Mechanism and regulation of perforin function
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批准号:nhmrc : 400041
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项目类别:NHMRC Project Grants
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资助金额:$29.35万
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财政年份:2006
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负责人:A/Pr Ilia Voskoboinik
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依托单位:
海外基金