Regulation and mechanisms of cytotoxic lymphocyte function

细胞毒性淋巴细胞功能的调节和机制

• 批准号: nhmrc : 1059126
• 负责人: A/Pr Ilia Voskoboinik
• 金额: $ 42.08万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-mechanisms-cytotoxic-lymphocyte-function/454734
• 关键词: Regulation; mechanisms; cytotoxic; lymphocyte; function

The immune system is the essential complex barrier that protects the organism for infections and some malignancies. Despite considerable efforts, the mechanism by which immune cells kill dangerous unwanted cells is poorly understood. This project will investigate the mechanism of action and the role in human pathologies of a key component of the immune system, a toxic protein perforin.

免疫系统是保护生物体免受感染和某些恶性肿瘤的基本复杂屏障。尽管付出了相当大的努力，免疫细胞杀死危险的不需要的细胞的机制仍然知之甚少。该项目将研究免疫系统的关键组成部分--一种有毒蛋白质穿孔素--的作用机制和在人类病理学中的作用。