Dissecting a Serial Killer: Investigating the Degranulation Pathways in Cytotoxic Lymphocytes
Dissecting a Serial Killer: Investigating the Degranulation Pathways in Cytotoxic Lymphocytes
批准号:
nhmrc : 1062990
负责人:
A/Pr Ilia Voskoboinik
金额:
$40.31万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2016-12-31
中文摘要
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英文摘要
When cells of the human body become cancerous or infected with virus, the body's immune system engages cytotoxic lymphocytes, known as "killer cells", that secrete an auxiliary of toxic proteins to eliminate these cells. The aim of this study is to investigate the mechanisms by which these critical immune cells accomplish this task. Importantly, humans who are genetically lacking in critical constituents of the cytotoxic lymphocyte are less able to fight off a viral infection and may be at a higher risk of developing cancer.
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