Dissecting a Serial Killer: Investigating the Degranulation Pathways in Cytotoxic Lymphocytes

剖析连环杀手：研究细胞毒性淋巴细胞的脱粒途径

• 批准号: nhmrc : 1062990
• 负责人: A/Pr Ilia Voskoboinik
• 金额: $ 40.31万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dissecting-serial-killer-cytotoxic-lymphocytes/455032
• 关键词: Dissecting; Serial; Killer; Investigating; Degranulation

When cells of the human body become cancerous or infected with virus, the body's immune system engages cytotoxic lymphocytes, known as "killer cells", that secrete an auxiliary of toxic proteins to eliminate these cells. The aim of this study is to investigate the mechanisms by which these critical immune cells accomplish this task. Importantly, humans who are genetically lacking in critical constituents of the cytotoxic lymphocyte are less able to fight off a viral infection and may be at a higher risk of developing cancer.

当人体细胞癌变或感染病毒时，人体的免疫系统就会动用被称为“杀伤细胞”的细胞毒性淋巴细胞，这些淋巴细胞会分泌一种辅助的有毒蛋白质来消灭这些细胞。本研究的目的是研究这些关键免疫细胞完成这一任务的机制。重要的是，基因上缺乏细胞毒性淋巴细胞关键成分的人抵抗病毒感染的能力较差，患癌症的风险可能更高。