Phasevarions of pathogenic Neisseria
Phasevarions of pathogenic Neisseria
批准号:
nhmrc : 519704
负责人:
Prof Michael Jennings
金额:
$37.2万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2010-12-31
中文摘要
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英文摘要
Certain bacterial DNA repeats are prone to hyper mutation. Genes with these repeats, Contingency genes, are randomly switched on and off. This process, phase variation , generates diversity in a population. Recently we described a new class of contingency gene that methylates DNA. On-off switching of this gene leads to random switching of multiple genes; the phasevarion . We will define the impact of this system in bacteria causing meningitis and STDs.
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Phasevarions of Haemophilus influenzae: mechanisms and origins of a novel epigenetic system controlling coordinated random switching in expression of multiple genes
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Novel vaccines and serotyping scheme for Haemophilus parasuis
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Glycosylation of pili in pathogenic Neisseria: function in disease and potential as a vaccine antigen
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Molecular mechanisms of pilin glycosylation in Neisseria: a model system for protein glycosylation in bacteria.
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依托单位:
Characterisation of HiaNm, a novel outer membrane from Neisseria meningitidis; vaccine potential and functional studies
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依托单位:
Phase variation of LPS expression in Neisseria meningitidis; role in pathogenesis and vaccine development.
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