Phasevarions of pathogenic Neisseria

致病性奈瑟菌的相变体

• 批准号: nhmrc : 519704
• 负责人: Prof Michael Jennings
• 金额: $ 37.2万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/phasevarions-pathogenic-neisseria/76575
• 关键词: Phasevarions; pathogenic; Neisseria

Certain bacterial DNA repeats are prone to hyper mutation. Genes with these repeats, Contingency genes, are randomly switched on and off. This process, phase variation , generates diversity in a population. Recently we described a new class of contingency gene that methylates DNA. On-off switching of this gene leads to random switching of multiple genes; the phasevarion . We will define the impact of this system in bacteria causing meningitis and STDs.

某些细菌的DNA重复序列容易发生超突变。具有这些重复序列的基因，即偶发基因，是随机开启和关闭的。这个过程，相位变化，在种群中产生多样性。最近，我们描述了一类新的偶然基因，它使DNA甲基化。这个基因的开关转换导致多个基因的随机转换;相位变化。我们将确定该系统对引起脑膜炎和性病的细菌的影响。