Targeting glycointeractions to generate new opportunities to treat and prevent bacterial infections.

针对糖相互作用创造治疗和预防细菌感染的新机会。

• 批准号: nhmrc : 1138466
• 负责人: Prof Michael Jennings
• 金额: $ 52.37万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-glycointeractions-generate-bacterial-infections/1318765
• 关键词: Targeting; glycointeractions; generate; new; opportunities

Bacteria and bacterial toxins can interact with complex sugar structures on human cells called glycans. My research team has identified new and important glycan interactions used by bacteria that cause diseases ranging from pneumonia, meningitis and food borne infections to urinary tract and sexually transmitted diseases. Now that these interactions have been discovered, they can be exploited to create drugs and vaccines that may treat and prevent disease by blocking the glycan interactions.

细菌和细菌毒素可以与人体细胞上称为聚糖的复杂糖结构相互作用。我的研究小组已经确定了细菌使用的新的和重要的聚糖相互作用，这些细菌引起的疾病从肺炎，脑膜炎和食源性感染到尿路和性传播疾病。既然这些相互作用已经被发现，它们可以被利用来创造药物和疫苗，通过阻断聚糖相互作用来治疗和预防疾病。