Characterisation of HiaNm, a novel outer membrane from Neisseria meningitidis; vaccine potential and functional studies

HiaNm(脑膜炎奈瑟菌的一种新型外膜)的表征;

基本信息

  • 批准号:
    nhmrc : 102599
  • 负责人:
  • 金额:
    $ 23.78万
  • 依托单位:
  • 依托单位国家:
    澳大利亚
  • 项目类别:
    NHMRC Project Grants
  • 财政年份:
    2000
  • 资助国家:
    澳大利亚
  • 起止时间:
    2000-01-01 至 2002-12-31
  • 项目状态:
    已结题

项目摘要

Meningococcal meningitis is a devastating illness which mostly affects children under 5 years. The clinical presentation is of a rapidly progressing disease with high rates of morbidity and mortality. This disease is caused by a bacterium, Neisseria meningitidis (the meningococcus). Vaccines are available against serogroup A and C strains of N. meningitidis, but not for group B strains, which cause the majority of disease in industrialised countries. We have recently identified a gene (designated hiaNm) which encodes a new protein which is located on the surface of the bacterium, in the outer membrane. There has been an enormous body of work done on the immunology, biochemistry and genetics of all components of the outer membrane of Neisseria meningitidis. Therefore the discovery of this novel protein provides an exciting opportunity to take a new direction in vaccine development. For an effective vaccine, the target molecule must be present in most strains; we have already shown that the hiaNm gene is present in all strains examined. In this proposal we describe a study of the vaccine potential and biological function of the hiaNm gene product HiaNm. We will express the protein at high levels, immunise mice, and produce antibodies against HiaNm to discover whether they can protect mice against meningococcal disease. At the completion of this set of experiments we will be in an excellent position to assess the potential for the further development of HiaNm as a component of a meningococcal vaccine.
脑膜炎球菌性脑膜炎是一种毁灭性的疾病,主要影响5岁以下的儿童。临床表现是一种快速进展的疾病,发病率和死亡率高。这种疾病是由一种细菌引起的,脑膜炎奈瑟氏菌(脑膜炎球菌)。针对血清群A和C的N.脑膜炎,但不适用于B组菌株,这导致工业化国家的大多数疾病。我们最近发现了一个基因(命名为hiaNm),该基因编码一种新蛋白质,该蛋白质位于细菌表面的外膜中。关于脑膜炎奈瑟氏菌外膜所有成分的免疫学、生物化学和遗传学,已经做了大量的工作。因此,这种新蛋白的发现为疫苗开发提供了一个令人兴奋的新方向。对于有效的疫苗,靶分子必须存在于大多数菌株中;我们已经表明,hiaNm基因存在于所有检测的菌株中。在这个建议中,我们描述了疫苗的潜力和生物学功能的hiaNm基因产物HiaNm的研究。我们将高水平表达该蛋白,免疫小鼠,并产生针对HiaNm的抗体,以发现它们是否可以保护小鼠免受脑膜炎球菌疾病的侵害。在完成这组实验后,我们将处于一个非常有利的位置,以评估进一步开发HiaNm作为脑膜炎球菌疫苗组分的潜力。

项目成果

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Prof Michael Jennings其他文献

Prof Michael Jennings的其他文献

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{{ truncateString('Prof Michael Jennings', 18)}}的其他基金

A “Goldilocks” live attenuated poultry vaccine for Infectious Coryza
用于传染性鼻炎的“Goldilocks”家禽减毒活疫苗
  • 批准号:
    LP210301365
  • 财政年份:
    2023
  • 资助金额:
    $ 23.78万
  • 项目类别:
    Linkage Projects
Genetic Basis of Variable Expression of Glycan Xeno-Autoantigens by Cattle
牛聚糖异种自身抗原变异表达的遗传基础
  • 批准号:
    DP200103734
  • 财政年份:
    2020
  • 资助金额:
    $ 23.78万
  • 项目类别:
    Discovery Projects
Targeting glycointeractions to generate new opportunities to treat and prevent bacterial infections.
针对糖相互作用创造治疗和预防细菌感染的新机会。
  • 批准号:
    nhmrc : GNT1138466
  • 财政年份:
    2018
  • 资助金额:
    $ 23.78万
  • 项目类别:
    Research Fellowships
Targeting glycointeractions to generate new opportunities to treat and prevent bacterial infections.
针对糖相互作用创造治疗和预防细菌感染的新机会。
  • 批准号:
    nhmrc : 1138466
  • 财政年份:
    2018
  • 资助金额:
    $ 23.78万
  • 项目类别:
    Research Fellowships
Glycointeractions
糖相互作用
  • 批准号:
    DP170104692
  • 财政年份:
    2017
  • 资助金额:
    $ 23.78万
  • 项目类别:
    Discovery Projects
The molecular mechanism of action of bacterial epigenetic regulators
细菌表观遗传调节因子作用的分子机制
  • 批准号:
    DP170104691
  • 财政年份:
    2017
  • 资助金额:
    $ 23.78万
  • 项目类别:
    Discovery Projects
The protein O-glycosylation pathway of Neisseria: a model system for O-glycosylation of bacterial proteins with potential use in biotechnology
奈瑟氏球菌的蛋白质 O-糖基化途径:细菌蛋白质 O-糖基化的模型系统,具有生物技术的潜在用途
  • 批准号:
    DP130103141
  • 财政年份:
    2013
  • 资助金额:
    $ 23.78万
  • 项目类别:
    Discovery Projects
The protein O-glycosylation pathway in Neisseria meningitidis
脑膜炎奈瑟菌的蛋白质O-糖基化途径
  • 批准号:
    DP110101058
  • 财政年份:
    2011
  • 资助金额:
    $ 23.78万
  • 项目类别:
    Discovery Projects
Role in disease and vaccine potential of cell surface o-linked glycoproteins in pathogenic Neisseria.
致病性奈瑟菌细胞表面 O 连接糖蛋白在疾病和疫苗潜力中的作用。
  • 批准号:
    nhmrc : 569737
  • 财政年份:
    2009
  • 资助金额:
    $ 23.78万
  • 项目类别:
    NHMRC Project Grants
Phasevarions of pathogenic Neisseria
致病性奈瑟菌的相变体
  • 批准号:
    nhmrc : 519704
  • 财政年份:
    2008
  • 资助金额:
    $ 23.78万
  • 项目类别:
    NHMRC Project Grants
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