Phasevarions of Haemophilus influenzae: mechanisms and origins of a novel epigenetic system controlling coordinated random switching in expression of multiple genes

流感嗜血杆菌的相变：控制多基因表达协调随机切换的新型表观遗传系统的机制和起源

• 批准号: DP0879604
• 负责人: Prof Michael Jennings
• 金额: $ 40.02万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0879604
• 关键词: Phasevarions; Haemophilus; influenzae; mechanisms; origins

Central to the utilisation of biological information is our ability to identify and interpret DNA sequence information from genomes. In bacteria that cause disease, these investigations can identify key aspects of the infectious process or potential components of vaccines or new targets for antibiotics. Our recent work has identified a new genetic system, the 'phasevarion', that mediates random expression of multiple genes. The proposed research aims to advance our understanding of gene expression at the most basic level, revealing how bacteria generate diverse populations to evade environmental and immune stresses, and facilitating improved interpretation and use of DNA sequences for researchers and industry in this field.

生物信息利用的核心是我们识别和解释基因组DNA序列信息的能力。在引起疾病的细菌中，这些研究可以确定感染过程的关键方面或疫苗的潜在成分或抗生素的新靶点。我们最近的工作已经确定了一个新的遗传系统，“相位变异”，介导多个基因的随机表达。这项研究旨在推进我们对基因表达的最基本理解，揭示细菌如何产生多样化的种群以逃避环境和免疫压力，并促进该领域研究人员和行业对DNA序列的解释和使用。