Analysis of antigen processing in melanoma cells, its influence on the success of cancer vaccination and enhancement in a combined-immunotherapy xenograft model of melanoma

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Cancer vaccines, an exciting new treatment option that aims to boost a patientÍs own immune system to fight a growing cancer, have shown great promise in developmental studies. Although these vaccines generate strong anti-cancer responses in the blood of treated patients, less than expected results have been observed in terms of increased patient survival. This project aims to understand how the cancer escapes recognition by the immune system and ways to enhance the effects of cancer vaccines.