Analysis of antigen processing in melanoma cells, its influence on the success of cancer vaccination and enhancement in a combined-immunotherapy xenograft model of melanoma

分析黑色素瘤细胞中的抗原加工及其对黑色素瘤联合免疫治疗异种移植模型中癌症疫苗接种成功和增强的影响

• 批准号: nhmrc : 1007381
• 负责人: Dr Ashley Knights
• 金额: $ 19.86万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/analysis-antigen-processing-model-melanoma/109216
• 关键词: Analysis; antigen; processing; melanoma; cells

Cancer vaccines, an exciting new treatment option that aims to boost a patientÍs own immune system to fight a growing cancer, have shown great promise in developmental studies. Although these vaccines generate strong anti-cancer responses in the blood of treated patients, less than expected results have been observed in terms of increased patient survival. This project aims to understand how the cancer escapes recognition by the immune system and ways to enhance the effects of cancer vaccines.

癌症疫苗是一种令人兴奋的新治疗选择，旨在增强patientÍs自身免疫系统以对抗不断增长的癌症，在发展研究中显示出巨大的希望。尽管这些疫苗在接受治疗的患者的血液中产生强烈的抗癌反应，但在增加患者生存方面观察到的结果不如预期。该项目旨在了解癌症如何逃脱免疫系统的识别，以及增强癌症疫苗效果的方法。