Functionalization of nanotextured biomaterial surfaces by ion implantation

由于各种原因，每年有数百万种由各种生物相容性材料制成的设备被放置在人体中。这些设备，包括骨科植入物和血管支架，相对有效，但仍需要显著改进。他们的寿命是有限的，他们的成功取决于病人的整体健康状况。此外，加拿大和其他工业化国家的人口老龄化正在产生对植入物的需求增加。因此，改进植入式装置是卫生部门的一个优先事项。已知细胞对电荷和局部电荷分布的变化作出反应。离子注入是一种基于等离子体的技术，可以精确地控制离子的深度，从而使表面的电荷分布可变。该技术已经被用于通过植入Ca和P离子来修饰ti基材料。在这里，我们建议将这种方法与我们的Ti和Ti合金的纳米织构方法结合起来，该方法已经取得了显著的成果，因为它大大加速了钙化组织的形成。这一步将帮助我们了解表面电荷分布在多大程度上影响细胞粘附和行为，这是一个基本价值的结果，但可以有效地应用于提高生物相容性。离子注入设备和专业知识代表了我们工业合作伙伴的核心专业知识。Plasmionique, Inc.不仅提供了大量的现金捐助（三年103,000美元），还提供了实物捐助，包括使用他们的等离子体表面改性设备和广泛的专业知识。

Millions of devices made from diverse biocompatible materials are placed in humans each year for a variety of reasons. These devices, which include orthopedic implants and vascular stents, are relatively effective but still need significant improvement. Their longevity is limited and their success depends on the patient's overall health. In addition, the aging population of Canada and other industrialized countries is generating an increased demand for implants. Improving implantable devices is therefore a priority for the health sector. Cells are known to respond to charges and variations in the local charge distribution. Ion implantation is a plasma-based technique that permits to insert ions with precise depth control, thereby allowing variable charge distribution at the surface. This technique has already been used to modify Ti-based materials by implanting Ca and P ions. Here we propose to combine this approach with our nanotexturing methodology for Ti and Ti alloys, which has already given outstanding results in that it greatly accelerates the formation of calcified tissues. This step will help us understand to what extent charge distribution at the surface affects cell adhesion and behavior in general, a result of fundamental value but which can be applied effectively to improve biocompatibility. Ion implantation equipment and expertise represent the core expertise of our industrial partner. Plasmionique, Inc. participates both with a significant cash contribution (103,000 $ over three years) as well as in kind, contributing the use of their equipment for plasma based modification of surfaces and their extensive expertise.