Axonal regeneration and degeneration: cellular and molecular mechanisms

轴突再生和变性：细胞和分子机制

• 批准号: nhmrc : 1111042
• 负责人: A/Pr Massimo Hilliard
• 金额: $ 42.93万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/axonal-regeneration-degeneration-molecular-mechanisms/663162
• 关键词: Axonal; regeneration; degeneration; cellular; molecular

Understanding how to repair of nerve damage following a traumatic injury, a vascular accident, or a degenerative condition, is essential to develop novel effective treatments. We have identified, in a simple genetic model system, the molecular mechanisms that allow a transected nerve to be repaired by reattachment of its two separated fragments. This 'axonal fusion' process is a highly promising innovative approach that can be exploited to restore the original neuronal circuit.

了解如何修复创伤性损伤、血管意外或退行性疾病后的神经损伤，对于开发新的有效治疗方法至关重要。我们已经确定，在一个简单的遗传模型系统，分子机制，使一个横断的神经修复其两个分离的片段重新连接。这种“轴突融合”过程是一种非常有前途的创新方法，可以用来恢复原始的神经元回路。