Epigenetic determination of neuronal vulnerability and neurodegenerative disease

神经元脆弱性和神经退行性疾病的表观遗传学测定

• 批准号: nhmrc : 1128381
• 负责人: A/Pr Massimo Hilliard
• 金额: $ 42.17万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/epigenetic-determination-neuronal-neurodegenerative-disease/948208
• 关键词: Epigenetic; determination; neuronal; vulnerability; neurodegenerative

Neurons are faced with diverse forms of stress everyday. Neural diseases exacerbate this stress, causing interference to genes that normally allow neurons to function correctly. As a result, neurons die, and severe loss can result in diseases such as dementia. We have discovered new molecular factors in neurons that insulate their genes from stress, thereby protecting neuron function and health. The proposed research will exploit these mechanisms to better protect neurons from disease.

神经元每天都面临着各种形式的压力。神经疾病加剧了这种压力，导致干扰正常允许神经元正常运作的基因。结果，神经元死亡，严重的损失可能导致痴呆等疾病。我们在神经元中发现了新的分子因子，可以使其基因免受压力，从而保护神经元的功能和健康。拟议的研究将利用这些机制来更好地保护神经元免受疾病的影响。