Identification and study of novel conserved molecule with an axonal protective function

具有轴突保护功能的新型保守分子的鉴定与研究

• 批准号: nhmrc : GNT1145896
• 负责人: A/Pr Massimo Hilliard
• 金额: $ 62.5万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-study-novel-protective-function/1348726
• 关键词: Identification; study; novel; conserved; molecule

Axonal degeneration is a common feature of a number of neurodegenerative conditions, such as motor neuron, Parkinson’s, Alzheimer’s and Huntington’s diseases. However, the genetic causes that regulate this biological event are poorly understood. We have identified a novel, conserved axonal protective molecule. We will study how it functions, and if it can be exploited to protect diseased neurons.

轴突变性是许多神经退行性疾病的共同特征，如运动神经元病、帕金森病、阿尔茨海默病和亨廷顿病。然而，调控这一生物事件的遗传原因却知之甚少。我们已经确定了一种新的，保守的轴突保护分子。我们将研究它的功能，以及是否可以利用它来保护患病的神经元。