Regulation of cytokine signalling: Structure and biophysical characterisation of key protiens

细胞因子信号传导的调节：关键蛋白质的结构和生物物理特征

• 批准号: nhmrc : 516777
• 负责人: Dr Jeffrey Babon
• 金额: $ 28.06万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-cytokine-signalling-key-protiens/115685
• 关键词: Regulation; cytokine; signalling; Structure; biophysical

Cells are informed when to grow, divide, migrate or die by protein molecules called cytokines. The cellular response to cytokines needs to be carefully regulated or else inflammation and other disorders will result. The SOCS (Suppressors Of Cytokine Signalling) family of proteins are a major regulator of cytokine signalling. This work will examine the structure and interactions of this important protein class.

细胞通过一种叫做细胞因子的蛋白质分子来决定何时生长、分裂、迁移或死亡。细胞对细胞因子的反应需要仔细调节，否则会导致炎症和其他疾病。SOCS（细胞因子信号抑制因子）蛋白家族是细胞因子信号的主要调节因子。这项工作将研究这类重要蛋白质的结构和相互作用。