Suppressor of cytokine signalling (SOCS4) is a critical regulator of the anti-viral immune response

细胞因子信号传导抑制因子 (SOCS4) 是抗病毒免疫反应的关键调节因子

• 批准号: nhmrc : 1023559
• 负责人: Dr Jeffrey Babon
• 金额: $ 41.14万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/suppressor-cytokine-signalling-immune-response/110282
• 关键词: Suppressor; cytokine; signalling; SOCS4; critical

The SOCS proteins are negative regulators of cytokine signalling and immune cell development and function. SOCS4 is the last remaining SOCS protein for which there is no described function or intracellular target. We intend to use well-defined acute and chronic viral disease models, and investigate the role of SOCS4 in infection in order to unravel its function. We will also search for its binding partners and intracellular targets, and determine the signalling pathways regulated by SOCS4.

SOCS 蛋白是细胞因子信号传导以及免疫细胞发育和功能的负调节因子。 SOCS4 是最后一个剩余的 SOCS 蛋白，没有描述其功能或细胞内靶点。我们打算使用明确的急性和慢性病毒性疾病模型，并研究 SOCS4 在感染中的作用，以揭示其功能。我们还将寻找其结合伙伴和细胞内靶点，并确定 SOCS4 调控的信号通路。