Regulation and function of the Zinc-finger protein ASCIZ in the DNA damage response

锌指蛋白 ASCIZ 在 DNA 损伤反应中的调节和功能

• 批准号: nhmrc : 1026125
• 负责人: A/Pr Jorg Heierhorst
• 金额: $ 42.68万
• 依托单位: St. Vincent's Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-function-zinc-damage-response/110470
• 关键词: Regulation; function; Zinc; finger; protein

Each human cell is exposed to more than 10,000 spontaneous DNA damage events per day. Inaccurate repair of this is damage is believed to be one of the key events in the onset of cancer. We have discovered a protein called ASCIZ that contributes to the repair of DNA base damage, and also has a separate function in the onset of lung development. Here we want to study in detail the mechanism of how it functions in DNA repair and thereby keeps mutation rates low and prevents the onset of cancer.

每个人体细胞每天都会遭受超过 10,000 次自发 DNA 损伤事件。这种损伤的不准确修复被认为是癌症发病的关键事件之一。我们发现了一种名为 ASCIZ 的蛋白质，它有助于修复 DNA 碱基损伤，并且在肺部发育的开始过程中也具有单独的功能。在这里，我们想要详细研究它如何在 DNA 修复中发挥作用，从而保持较低的突变率并预防癌症的发生。