Identification of telomere-specific recombination pathways

端粒特异性重组途径的鉴定

• 批准号: nhmrc : 502600
• 负责人: A/Pr Jorg Heierhorst
• 金额: $ 36.01万
• 依托单位: St. Vincent's Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-telomere-specific-recombination-pathways/78026
• 关键词: Identification; telomere; specific; recombination; pathways

Human cells stop to grow when the natural ends of chromosomes become too short. One way of how cancer cells evade this growth arrest is by using a copy-mechanism to extend short chromosome ends. Ironically, this copy mechanism is usually used by cells to keep the structure of chromosomes intact in order to prevent mutations that cause cancer. Here we will study a novel protein that contributes to the copy mechanism at short chromosome ends, but not as much in normal mutation prevention.

当染色体的自然末端变得太短时，人类细胞就会停止生长。癌细胞如何逃避这种生长停滞的一种方法是通过使用复制机制来延长短染色体末端。具有讽刺意味的是，这种复制机制通常被细胞用来保持染色体结构的完整，以防止导致癌症的突变。在这里，我们将研究一种新的蛋白质，它有助于短染色体末端的复制机制，但在正常突变预防中没有那么多。