Multi-domain regulation of DNA damage response kinases

DNA 损伤反应激酶的多域调控

• 批准号: nhmrc : 1009764
• 负责人: A/Pr Jorg Heierhorst
• 金额: $ 20.9万
• 依托单位: St. Vincent's Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/multi-domain-regulation-response-kinases/109425
• 关键词: Multi; domain; regulation; DNA; damage

DNA damage plays a key role in the onset of cancer and the response to cancer therapies. Mutations in the Chk2 DNA damage response kinase are associated with increased cancer risk. We will study detailed mechanisms how phosphorylation of Chk2-like kinases contributes to normal copying of our DNA every time a cell divides, and how it regulates how Chk2 is activated. The studies will improve our understanding how cancer may originate and how cancer cells respond to chemo- or radiation therapy.

DNA损伤在癌症的发病和对癌症治疗的反应中起着关键作用。Chk2 DNA损伤反应激酶的突变与癌症风险增加有关。我们将研究Chk2样激酶的磷酸化如何在细胞每次分裂时有助于我们DNA的正常复制，以及它如何调节Chk2如何被激活的详细机制。这些研究将提高我们对癌症如何起源以及癌细胞如何对化疗或放疗做出反应的理解。