A tumour suppressor pathway that removes DNA-RNA hybrids

消除 DNA-RNA 杂交体的肿瘤抑制途径

• 批准号: nhmrc : 1139099
• 负责人: A/Pr Jorg Heierhorst
• 金额: $ 63.27万
• 依托单位: St. Vincent's Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/tumour-suppressor-pathway-rna-hybrids/1318927
• 关键词: tumour; suppressor; pathway; removes; DNA

DNA:RNA hybrids are found normally in our chromosomes. But, the regions where DNA:RNA hybrids form are linked to chromosome changes that occur during breast and blood cancer development. We have uncovered why these chromosome changes occur, and have linked it to the important function of a cancer-associated gene called FANCM. Our study is exploring this important finding that has implications for both the cause and treatment of cancer.

DNA：RNA杂交体通常存在于我们的染色体中。但是，DNA：RNA杂交体形成的区域与乳腺癌和血癌发展过程中发生的染色体变化有关。我们已经揭示了这些染色体变化发生的原因，并将其与称为FANCM的癌症相关基因的重要功能联系起来。我们的研究正在探索这一重要发现，它对癌症的病因和治疗都有影响。