Functions of ASCIZ in the repair of accidental and programmed DNA base damage

ASCIZ 在修复意外和程序性 DNA 碱基损伤中的功能

• 批准号: nhmrc : 559020
• 负责人: A/Pr Jorg Heierhorst
• 金额: $ 40.88万
• 依托单位: St. Vincent's Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/functions-asciz-repair-base-damage/94473
• 关键词: Functions; ASCIZ; repair; accidental; programmed

Every cell in the body encounters approximately 10,000 DNA base lesions per day. If not accurately repaired, this DNA damage may give rise to cancer. We have discovered a new protein called ASCIZ that is involved in the cellular response to base damage. We believe that ASCIZ functions by promoting the most efficient way to repair damaged DNA bases. We will investigate this hypothesis using cells that lack the ASCIZ gene, and also test if defective ASCIZ leads to increased cancer.

身体的每个细胞每天都会遭遇大约10,000个DNA碱基损伤。如果不能准确修复，这种DNA损伤可能会导致癌症。我们发现了一种名为ASCIZ的新蛋白质，它参与了细胞对碱基损伤的反应。我们认为ASCIZ的功能是通过促进最有效的方式修复受损的DNA碱基。我们将使用缺乏ASCIZ基因的细胞来研究这一假设，并测试ASCIZ缺陷是否会导致癌症的增加。