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Functions of ASCIZ in the repair of accidental and programmed DNA base damage

Functions of ASCIZ in the repair of accidental and programmed DNA base damage
ASCIZ 在修复意外和程序性 DNA 碱基损伤中的功能
批准号：
nhmrc : 559020
负责人：
A/Pr Jorg Heierhorst
金额：
$40.88万
依托单位：
St. Vincent's Institute of Medical Research
依托单位国家：
澳大利亚
项目类别：
NHMRC Project Grants
财政年份：
2009
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2009-01-01 至 2011-12-31
来源：
https://researchdata.edu.au/functions-asciz-repair-base-damage/94473
关键词：
FunctionsASCIZrepairaccidentalprogrammed

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中文摘要
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英文摘要
Every cell in the body encounters approximately 10,000 DNA base lesions per day. If not accurately repaired, this DNA damage may give rise to cancer. We have discovered a new protein called ASCIZ that is involved in the cellular response to base damage. We believe that ASCIZ functions by promoting the most efficient way to repair damaged DNA bases. We will investigate this hypothesis using cells that lack the ASCIZ gene, and also test if defective ASCIZ leads to increased cancer.
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会议论文
A tumour suppressor pathway that removes DNA-RNA hybrids
  • 批准号：
    nhmrc : GNT1139099
  • 项目类别：
    Project Grants
  • 资助金额：
    $93.58万
  • 财政年份：
    2018
  • 负责人：
    A/Pr Jorg Heierhorst
  • 依托单位：
A tumour suppressor pathway that removes DNA-RNA hybrids
Research Fellowship
Regulation and function of the Zinc-finger protein ASCIZ in the DNA damage response
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