课题基金 / 基金详情

Research Fellowship

Research Fellowship
研究奖学金
批准号:
nhmrc : 1022469
负责人:
A/Pr Jorg Heierhorst
金额:
$45.06万
依托单位国家:
澳大利亚
项目类别:
Research Fellowships
财政年份:
2012
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2012-01-01 至 2016-12-31
关键词:

项目摘要

项目成果

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中文摘要
翻译
DNA损伤反应途径在预防癌症的发生和调节对化疗药物的临床反应中起着重要作用,并且一些相关蛋白在正常发育过程中具有额外的功能。该奖学金将研究一种新的人类蛋白质,该蛋白质在肺的形成中具有关键作用,其在预防正常氧化损伤对DNA的破坏性后果中的作用,以及参与预防基因组突变的其他基本机制。
英文摘要
DNA damage response pathways play important roles in preventing the onset of cancer and regulating the clinical response to chemotherapeutics, and some of the relevant proteins have additional functions during normal development. This fellowship will study new a human protein with key roles in the formation of the lung, and its roles in preventing devastating consequences of normal oxidative damage to DNA, as well as additional fundamental mechanisms involved in preventing genome mutations.
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会议论文
A tumour suppressor pathway that removes DNA-RNA hybrids
  • 批准号:
    nhmrc : GNT1139099
  • 项目类别:
    Project Grants
  • 资助金额:
    $93.58万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Jorg Heierhorst
  • 依托单位:
A tumour suppressor pathway that removes DNA-RNA hybrids
Regulation and function of the Zinc-finger protein ASCIZ in the DNA damage response
Multi-domain regulation of DNA damage response kinases
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