New chirons and catalysts in asymmetric and general organic synthesis

不对称和一般有机合成中的新凯龙和催化剂

• 批准号: 194282-2007
• 负责人: McNulty, James
• 金额: $ 3.28万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2007
• 资助国家: 加拿大
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=366252
• 关键词: New; chirons; catalysts; asymmetric; general

This work involves the synthesis of novel highly functionalized chiral and achiral fragments from carbohydrate precursors.This work also involves investigation into the design of new ligands as catalyst components in cross-coupling and other reactions.This work also involves investigation into synthetic methodology that will affect various coupling methods using chiral auxiliaries and catalysts.Applications of the methods developed include the synthesis of potential anticancer and antibacterial agents and high value fine chemical intermediates.The work will also involve the isolation and structural determination of Natural products.

这项工作涉及从碳水化合物前体合成新型高度功能化的手性和非手性片段。​​这项工作还涉及研究设计新配体作为交叉偶联和其他反应中的催化剂组分。这项工作还涉及研究影响使用手性助剂和催化剂的各种偶联方法的合成方法。所开发的方法的应用包括 潜在的抗癌和抗菌药物以及高价值精细化工中间体的合成。该工作还将涉及天然产物的分离和结构测定。