The role of EphA2 signalling and environmental modifiers in cataract.

EphA2 信号传导和环境调节剂在白内障中的作用。

• 批准号: nhmrc : 1009955
• 负责人: A/Pr Kathryn Burdon
• 金额: $ 39.44万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-epha2-signalling-modifiers-cataract/109446
• 关键词: role; EphA2; signalling; environmental; modifiers

In cataract the clear lens in the eye becomes opaque causing blindness. Cataract is very common in the elderly, but is rarely also seen in babies and children. In babies certain gene defects, and in the elderly the genes and environmental factors contribute to cataract. The EPHA2 gene causes cataract in both young and old people. This project aims to understand how EPHA2 and other related genes cause cataract in young and old people, to prevent, delay or improve its treatment in the future.

白内障时，眼睛里透明的透镜变得不透明，导致失明。白内障在老年人中很常见，但在婴儿和儿童中也很少见。在婴儿中，某些基因缺陷，以及在老年人中，基因和环境因素导致白内障。EPHA2基因在年轻人和老年人中都会导致白内障。该项目旨在了解EPHA2和其他相关基因如何导致青少年和老年人白内障，以预防，延迟或改善其未来的治疗。