Molecular genetic risk factors and mechanisms in blinding eye disease

致盲眼病的分子遗传危险因素和机制

• 批准号: nhmrc : 1059954
• 负责人: A/Pr Kathryn Burdon
• 金额: $ 42.08万
• 依托单位: Antarctic Climate and Ecosystems CRC, University of Tasmania
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-genetic-risk-eye-disease/454793
• 关键词: Molecular; genetic; risk; factors; mechanisms

This project aims to understand the genetic causes of blinding eye diseases. We have recently identified genetic variation that contributes to the risk of glaucoma and diabetic eye disease. We are exploring the mechanisms through which this leads to disease by looking at differences in the genes in patients with disease compared to unaffected individuals. We hope to be able to identify genes that could be the target of new therapies to prevent blindness and visual impairment in the community.

该项目旨在了解致盲性眼病的遗传原因。我们最近发现了导致青光眼和糖尿病性眼病风险的遗传变异。我们正在通过观察疾病患者与未受影响的个体相比基因的差异来探索导致疾病的机制。我们希望能够识别出可能成为新疗法靶点的基因，以预防社区中的失明和视力障碍。