New methods for the synthesis of biaryl compunds

联芳基结构基序的实用性已经促使针对开发高效且高产率的合成方法的密集研究。 过渡金属催化在这些努力中具有突出的特点，导致建立了一系列有用的交叉偶联反应。 所有这些方法中的一个共同要素是需要两种可以选择性地与金属催化剂反应的活化芳烃。 虽然可以用预活化的底物实现高产率，但是需要双重预活化本质上是浪费的，因为这些基团可能需要多个步骤来安装。 此外，并非有机金属或芳基卤化物的所有区域异构体都容易获得，使得一些联芳基化合物难以获得。 在某些情况下，预活化物质可能不稳定，因此使该方法的应用复杂化。 该提议的目标是开发新的金属催化反应，用于制备需要较少或不需要预活化步骤的联芳基分子。 一旦成功，新的反应应该在制备这类重要化合物中找到重要的应用。

The utility of the biaryl structural motif has prompted intense research directed at the development of efficient and high yielding synthetic methods. Transition metal catalysis has featured prominently in these efforts, leading to the establishment of a range of useful cross coupling reactions. A common element in all of these processes is the need for two activated arenes that can react selectively with the metal catalyst. While high yields can be achieved with pre-activated substrates, the need for dual pre-activation is inherently wasteful since these groups may require multiple steps for their installation. Furthermore, not all regioisomers of the organometallic or aryl halide are readily available making some biaryl compounds difficult to access. In some instances the pre-activated species may not be stable thus complicating application of this methodology. This proposal targets the development of new metal catalyzed reactions for the preparation of biaryl molecules that require less, or no pre-activation steps. Once successful, the new reactions should find significant application in the preparation of this important class of compound.