New methods for the synthesis of biaryl compounds

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The utility of the biaryl structural motif has prompted intense research directed at the development of efficient and high yielding synthetic methods. Transition metal catalysis has featured prominently in these efforts, leading to the establishment of a range of useful cross coupling reactions. A common element in all of these processes is the need for two activated arenes that can react selectively with the metal catalyst. While high yields can be achieved with pre-activated substrates, the need for dual pre-activation is inherently wasteful since these groups may require multiple steps for their installation. Furthermore, not all regioisomers of the organometallic or aryl halide are readily available making some biaryl compounds difficult to access. In some instances the pre-activated species may not be stable thus complicating application of this methodology. This proposal targets the development of new metal catalyzed reactions for the preparation of biaryl molecules that require less, or no pre-activation steps. Once successful, the new reactions should find significant application in the preparation of this important class of compound.