New methods for the synthesis of biaryl compunds

联芳基结构基序的应用促进了对高效高产合成方法的研究。过渡金属催化在这些努力中具有突出的特点，导致建立了一系列有用的交叉偶联反应。所有这些过程的一个共同要素是需要两种能够选择性地与金属催化剂反应的活化芳烃。虽然预活化底物可以实现高产量，但由于这些基团可能需要多个步骤来安装，因此需要双重预活化本身就是浪费。此外，并不是所有的有机金属或芳基卤化物的区域异构体都是容易获得的，这使得一些联芳基化合物难以获得。在某些情况下，预激活的物种可能不稳定，从而使该方法的应用复杂化。该建议的目标是开发新的金属催化反应，以制备联芳基分子，需要较少的预活化步骤，或没有预活化步骤。一旦成功，新的反应将在这类重要化合物的制备中找到重要的应用。

The utility of the biaryl structural motif has prompted intense research directed at the development of efficient and high yielding synthetic methods. Transition metal catalysis has featured prominently in these efforts, leading to the establishment of a range of useful cross coupling reactions. A common element in all of these processes is the need for two activated arenes that can react selectively with the metal catalyst. While high yields can be achieved with pre-activated substrates, the need for dual pre-activation is inherently wasteful since these groups may require multiple steps for their installation. Furthermore, not all regioisomers of the organometallic or aryl halide are readily available making some biaryl compounds difficult to access. In some instances the pre-activated species may not be stable thus complicating application of this methodology. This proposal targets the development of new metal catalyzed reactions for the preparation of biaryl molecules that require less, or no pre-activation steps. Once successful, the new reactions should find significant application in the preparation of this important class of compound.