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Specific roles of the transmembrane exoloops and the LDLa module in the activity of relaxin and INSL3 receptors

Specific roles of the transmembrane exoloops and the LDLa module in the activity of relaxin and INSL3 receptors
跨膜外环和 LDLa 模块在松弛素和 INSL3 受体活性中的具体作用
批准号:
nhmrc : 628427
负责人:
A/Pr Paul Gooley
金额:
$39.93万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-01 至 2012-12-31

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中文摘要
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英文摘要
The peptide hormone relaxin is currently in clinical trials to treat acute heart failure. The related hormone INSL3 has important roles in fertility. We will continue our previously successful approaches to study the interaction of relaxin and INSL3 with their cell surface receptors and the mechanisms by which the receptors function. The knowledge gained will aid in the design of smaller, more potent and orally active forms of relaxin and INSL3 for future clinical applications.
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Molecular determinants of drug binding and selectivity at muscarinic acetylcholine receptors
  • 批准号:
    nhmrc : 1138448
  • 项目类别:
    Project Grants
  • 资助金额:
    $55.23万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Paul Gooley
  • 依托单位:
Molecular determinants of drug binding and selectivity at muscarinic acetylcholine receptors
  • 批准号:
    nhmrc : GNT1138448
  • 项目类别:
    Project Grants
  • 资助金额:
    $81.69万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Paul Gooley
  • 依托单位:
Resolving and targeting the complex molecular mechanisms underlying GPCR signalling
  • 批准号:
    nhmrc : 1141034
  • 项目类别:
    Project Grants
  • 资助金额:
    $72.44万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Paul Gooley
  • 依托单位:
Resolving and targeting the complex molecular mechanisms underlying GPCR signalling
  • 批准号:
    nhmrc : GNT1141034
  • 项目类别:
    Project Grants
  • 资助金额:
    $107.14万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Paul Gooley
  • 依托单位:
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