Specific roles of the transmembrane exoloops and the LDLa module in the activity of relaxin and INSL3 receptors

跨膜外环和 LDLa 模块在松弛素和 INSL3 受体活性中的具体作用

• 批准号: nhmrc : 628427
• 负责人: A/Pr Paul Gooley
• 金额: $ 39.93万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/specific-roles-transmembrane-insl3-receptors/82145
• 关键词: Specific; roles; transmembrane; exoloops; LDLa

The peptide hormone relaxin is currently in clinical trials to treat acute heart failure. The related hormone INSL3 has important roles in fertility. We will continue our previously successful approaches to study the interaction of relaxin and INSL3 with their cell surface receptors and the mechanisms by which the receptors function. The knowledge gained will aid in the design of smaller, more potent and orally active forms of relaxin and INSL3 for future clinical applications.

肽激素松弛素目前正在进行治疗急性心力衰竭的临床试验。相关激素 INSL3 在生育方面发挥着重要作用。我们将继续我们之前成功的方法来研究松弛素和 INSL3 与其细胞表面受体的相互作用以及受体发挥作用的机制。获得的知识将有助于设计更小、更有效和口服活性的松弛素和 INSL3，以用于未来的临床应用。