Novel approaches to understanding peptide G-protein-coupled receptor activation

了解肽 G 蛋白偶联受体激活的新方法

• 批准号: nhmrc : GNT1081844
• 负责人: A/Pr Paul Gooley
• 金额: $ 42.95万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-approaches-understanding-receptor-activation/1345419
• 关键词: Novel; approaches; understanding; peptide; protein

G protein-coupled receptors (GPCRs) are proteins that exist on every human cell, where they sense, and respond to environmental stimuli. Because of their importance they are targeted by drugs to treat many diseases. However little is known about the molecular steps that underlie cellular responses upon drug binding and this has hindered new drug development. This project uses new technology to determine the complex pathway of GPCR activation upon drug binding which will aid new drug development.

G蛋白偶联受体(GPCRs)是存在于每个人类细胞上的蛋白质，它们在那里感知并对环境刺激做出反应。由于它们的重要性，它们是治疗许多疾病的药物的靶点。然而，人们对药物结合后细胞反应的分子步骤知之甚少，这阻碍了新药的开发。该项目利用新技术来确定药物结合时GPCR激活的复杂途径，这将有助于新药的开发。